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Showing results 1 - 100 of 165:
Lifespan Observation Mus musculus (129 SvEv)
  • Gene Intervention: p66shc (heterzygous) deletion / null
median lifespan increased 7.1% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316) matalpha
  • Gene Intervention: PDE2 deletion / null
mean lifespan decreased -25.69% (significant)
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Lifespan Observation Saccharomyces cerevisiae (DBY746)
  • Gene Intervention: SCH9 (mTn) non-null recessive
mean lifespan increased 33.33% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (human SOD1 driven by D42-GAL4) over-expression
mean lifespan increased 41.24% (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: MsrA deletion / null
lifespan decreased (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: chico non-null recessive
lifespan increased (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: chico non-null recessive
lifespan increased (significant)
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Lifespan Observation Drosophila melanogaster (Canton-S, cn bw)
  • Gene Intervention: EcR non-null recessive
lifespan increased (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: aat-8 RNAi knockdown
lifespan increased 30% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: amt-2 RNAi knockdown
lifespan increased 20% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: asm-3 RNAi knockdown
lifespan increased 50% (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: Atg7 deletion / null
lifespan increased 33% (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: Atg8a over-expression
lifespan increased 56% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: B0228.5 deletion / null
lifespan increased 81% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: B0546.3 RNAi knockdown
lifespan increased 27% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: bar-1 deletion / null
lifespan increased 45% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: C33A12.1 RNAi knockdown
lifespan increased 40% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: C39E9.6 RNAi knockdown
lifespan increased 18% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: C40H1.5 RNAi knockdown
lifespan increased 14% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: C42C1.3 RNAi knockdown
lifespan increased 60% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: C46G7.2 RNAi knockdown
lifespan increased 44% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: C47E12.2 RNAi knockdown
lifespan increased 36% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: cyp-33E2 RNAi knockdown
lifespan increased 18% (significant)
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Lifespan Observation Drosophila melanogaster (DJ-1α)
  • Gene Intervention: DJ-1alpha RNAi knockdown
lifespan decreased -55.26% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: E04A4.7 RNAi knockdown
lifespan increased 80% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: elt-6 RNAi knockdown
lifespan increased 34% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: epc-1 RNAi knockdown
lifespan increased 20% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: ers-1 RNAi knockdown
lifespan increased 40% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F01G10.1 RNAi knockdown
lifespan increased 25% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F08B4.7 RNAi knockdown
lifespan increased 21% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F09G8.3 RNAi knockdown
lifespan increased 60% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F13B6.1 RNAi knockdown
lifespan increased 50% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F21D5.8 RNAi knockdown
lifespan increased 36% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F29C4.2 RNAi knockdown
lifespan increased 100% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F33D4.5 RNAi knockdown
lifespan increased 45% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F41A4.1 RNAi knockdown
lifespan increased 28% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F42A6.1 RNAi knockdown
lifespan increased 22% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F49C12.9 RNAi knockdown
lifespan increased 19% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: F56D5.5 RNAi knockdown
lifespan increased 20% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: frh-1 RNAi knockdown
mean lifespan increased 27.95% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: gei-9 RNAi knockdown
lifespan increased 57% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: grl-19 RNAi knockdown
lifespan increased 27% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: hhat-2 RNAi knockdown
lifespan increased 50% (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: hsp68 over-expression
lifespan increased 20% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: inx-8 RNAi knockdown
lifespan increased 19% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: K07H8.8 RNAi knockdown
lifespan increased 22% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: K12H4.5 RNAi knockdown
lifespan increased 58% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: LLC1.3 RNAi knockdown
lifespan increased 61% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: mrs-1 RNAi knockdown
lifespan increased 23% (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: MSRA over-expression
lifespan increased 70% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: pod-1 over-expression
lifespan increased 45% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: ral-1 RNAi knockdown
lifespan increased 19% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: rps-23 RNAi knockdown
lifespan increased 126% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: rps-5 RNAi knockdown
lifespan increased 75% (significant)
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: Sod2 RNAi knockdown
lifespan increased 81% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: T05A1.5 RNAi knockdown
lifespan increased 20% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: T20H4.5 RNAi knockdown
lifespan increased 51% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: T22B11.5 RNAi knockdown
lifespan increased 79% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: T28A8.6 RNAi knockdown
lifespan increased 28% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: T28D6.4 RNAi knockdown
lifespan increased 33% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: tag-174 RNAi knockdown
lifespan increased 11% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: tag-224 RNAi knockdown
lifespan increased 60% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: tag-61 RNAi knockdown
lifespan increased 40% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: tag-99 RNAi knockdown
lifespan increased 20% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: tba-7 RNAi knockdown
lifespan increased 13% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: tufm-1 RNAi knockdown
lifespan increased 89% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Txn1 over-expression
lifespan increased 35% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: ucr-1 RNAi knockdown
lifespan increased 20% (significant)
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Lifespan Observation Saccharomyces cerevisiae
  • Gene Intervention: Ump1 over-expression
lifespan increased (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: W03G1.5 RNAi knockdown
lifespan increased 54% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: W09D10.3 RNAi knockdown
lifespan increased 51% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: Y37D8A.18 RNAi knockdown
lifespan increased 39% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: Y38C1AA.3 over-expression
mean lifespan decreased -4.37%
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: Y43F4B.7 RNAi knockdown
lifespan increased 11% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: Y66A7A.1 RNAi knockdown
lifespan increased 25% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: Y69A2AR.19 RNAi knockdown
lifespan increased 19% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: Y76A2B.3 RNAi knockdown
lifespan increased 52% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: yrs-1 RNAi knockdown
lifespan increased 55% (significant)
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Lifespan Observation Caenorhabditis elegans (rrf-3(pk1426))
  • Gene Intervention: ZK809.3 RNAi knockdown
lifespan increased 100% (significant)
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Lifespan Observation Drosophila melanogaster (w1118) female
  • Gene Intervention: NIP RNAi knockdown
median lifespan decreased -75% (significant)
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Lifespan Observation Drosophila melanogaster (w1118) female
  • Gene Intervention: NIP RNAi knockdown
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Lifespan Observation Mus musculus (129 SvEv)
  • Gene Intervention: p66shc (homozygous) deletion / null
median lifespan increased 27.86% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan decreased -23.56% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan decreased -26.96% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan decreased -17.91% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan increased 14.02% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan decreased -5.17%
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan increased 17.95% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: oxy-4 unknown
mean lifespan increased 9.92% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: CG7207 loss of function
mean lifespan decreased -75% (significant)
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Lifespan Observation Drosophila melanogaster female
  • Gene Intervention: CG7207 loss of function
mean lifespan decreased -71.43% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: cst-1 RNAi knockdown
lifespan decreased -13.33% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: cst-1 RNAi knockdown
mean lifespan decreased -18.75% (significant)
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Lifespan Observation Drosophila melanogaster (DJ-1βA286)
  • Gene Intervention: dj-1beta loss of function
mean lifespan decreased -24% (significant)
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Lifespan Observation Mus musculus (ICR/CD-1) female
  • Environment Intervention: Environmental enrichment
median lifespan increased 6.52% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (human SOD1 driven by D42-GAL4) over-expression
mean lifespan increased 16.09% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (x39) loss of function
mean lifespan decreased -96.17% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (human SOD1 driven by D42-GAL4) over-expression
  • Gene Intervention: SOD1 (x39) loss of function
mean lifespan decreased -67.43% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (human SOD1 driven by D42-GAL4) over-expression
  • Gene Intervention: SOD1 (x39) loss of function
mean lifespan decreased -27.2% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: mev-1 (kn1) loss of function
  • Environment Intervention: Reduced oxygen
mean lifespan decreased -34.62% (significant)
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