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Showing results 1 - 59 of 59:
Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -44.14% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -41.41% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
mean lifespan decreased -47.27% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
  • Environment Intervention: dietary restriction
mean lifespan increased 25.27% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 61.17% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan increased 1.1%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
mean lifespan increased 0.73%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST1 deletion / null
mean lifespan decreased -0.76%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST2 deletion / null
mean lifespan decreased -0.76%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST3 deletion / null
mean lifespan decreased -28.79% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
mean lifespan decreased -2.27%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
mean lifespan decreased -47.35% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST2 deletion / null
mean lifespan decreased -3.94%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 10.34% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 19.54% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan decreased -11.49% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
mean lifespan decreased -48.66% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -54.02% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST1 deletion / null
mean lifespan increased 0.38%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST2 deletion / null
mean lifespan increased 0.38%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST3 deletion / null
mean lifespan decreased -32.95% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST3 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -83.52% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST3 deletion / null
  • Compound Intervention: nicotinamide (25 millimolar)
mean lifespan decreased -83.91% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
  • Compound Intervention: nicotinamide (25 millimolar)
mean lifespan decreased -72.8% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -49.43% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
mean lifespan decreased -2.68%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
  • Gene Intervention: HST3 deletion / null
mean lifespan decreased -78.54% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
  • Gene Intervention: HST3 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -85.82% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HST4 deletion / null
  • Gene Intervention: HST3 deletion / null
  • Compound Intervention: nicotinamide (25 millimolar)
mean lifespan decreased -84.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
mean lifespan increased 3.45%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 17.62% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 68.2% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 57.09% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan increased 5.75%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
  • Environment Intervention: dietary restriction
mean lifespan increased 31.03% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
mean lifespan increased 1.15%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 53.64% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 75.86% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST2 deletion / null
mean lifespan increased 11.11%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST3 deletion / null
mean lifespan decreased -36.02% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST3 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 15.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 76.63% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST4 deletion / null
mean lifespan decreased -13.79%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
mean lifespan increased 6.13%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 19.92% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 61.3% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 67.05% (significant)
more >
Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
mean lifespan increased 6.51%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 29.89% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan decreased -2.3%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
  • Environment Intervention: dietary restriction
mean lifespan increased 2.3%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Gene Intervention: HST3 deletion / null
mean lifespan decreased -73.56% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Gene Intervention: HST3 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan decreased -75.1% (significant)
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Lifespan Observation Saccharomyces cerevisiae (W303AR5 ) mata
  • Gene Intervention: HST4 deletion / null
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Compound Intervention: nicotinamide (25 mM)
mean lifespan decreased -29.53% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: daf-16 (mu86) loss of function
  • Compound Intervention: nicotinamide (25 mM)
mean lifespan decreased -40.41% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: daf-2 (e1370) loss of function
  • Compound Intervention: nicotinamide (25 mM)
mean lifespan decreased -66.84% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: nicotinamide (1 mM)
max lifespan decreased (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: nicotinamide (5 mM)
max lifespan decreased (significant)
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