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Showing results 1 - 36 of 36:
Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 6.67%
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 7.95% (significant)
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Lifespan Observation Rattus norvegicus (Fischer-344) male
  • Compound Intervention: metformin (300 mg/kg/day)
lifespan increased 2.27%
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Lifespan Observation Rattus norvegicus (Fischer-344) male
  • Environment Intervention: dietary restriction
lifespan increased 8.8% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 14.09% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
median lifespan increased 17.52% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
max lifespan increased 3.29% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 20.71% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 6.17% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
median lifespan increased 6.6% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
max lifespan decreased -9.14% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 7.06% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan decreased -3.14%
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
median lifespan decreased (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
max lifespan increased 2.66%
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan decreased -12.8% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (25 mM)
mean lifespan increased 18.33% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
mean lifespan increased 36.33% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (100 mM)
mean lifespan increased 3.4% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Phenformin (1.5 mM)
mean lifespan increased 5.36% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Phenformin (3 mM)
mean lifespan increased 20.66% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Phenformin (4.5 mM)
mean lifespan increased 26.38% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (25 mM)
mean lifespan increased 8.03% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
mean lifespan increased 1.51%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (100 mM)
mean lifespan decreased -15.98% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (2 mM)
  • Environment Intervention: Diet
mean lifespan decreased -2.14%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (10 mM)
  • Environment Intervention: Diet
mean lifespan decreased -6.27% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
mean lifespan increased 25.44% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
  • Compound Intervention: Carbenicillin (4 mM)
mean lifespan increased 23.67% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
  • Environment Intervention: Diet
mean lifespan increased 9.44% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
lifespan increased 13.9% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
mean lifespan increased 33.3% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: Metformin (50 mM)
mean lifespan increased 38.63% (significant)
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