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Showing results 1 - 100 of 362:
Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RTG3 deletion / null
median lifespan increased 63.64% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RTG3 deletion / null
  • Environment Intervention: dietary restriction
median lifespan increased 109.09% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: fer-15 (b26) non-null recessive
median lifespan decreased -11.76% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: atgr-7 RNAi knockdown
lifespan increased 23% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: atgr-7 RNAi knockdown
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: pha-4 RNAi knockdown
lifespan increased 25% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: pha-4 over-expression
lifespan increased 23% (significant)
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Lifespan Observation Caenorhabditis elegans
  • Gene Intervention: skn-1 RNAi knockdown
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Lifespan Observation
  • Environment Intervention: Dietary restriction
mean lifespan increased 35% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 32.66% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 14.11% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 21.37% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 29.44% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 69.35% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 64.52% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: SIR2 over-expression
  • Environment Intervention: Dietary restriction
mean lifespan increased 62.07% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 21.84% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 30% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 130% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: Dietary restriction
mean lifespan increased 80% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: pex5 deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan decreased -70% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: pex5 deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan decreased -50% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: pex5 deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan decreased -20% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Environment Intervention: Dietary restriction
mean lifespan increased 47.3% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Environment Intervention: Dietary restriction
mean lifespan increased 58.56% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Environment Intervention: Dietary restriction
mean lifespan increased 22.41% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: eat-2 (ad465) loss of function
mean lifespan increased 26.07% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: eat-2 (ad465) loss of function
mean lifespan increased 32.07% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: eat-2 (ad465) loss of function
  • Gene Intervention: hif-1 RNAi knockdown
mean lifespan increased 20.38% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: eat-2 (ad465) loss of function
  • Gene Intervention: hif-1 RNAi knockdown
mean lifespan increased 21.74% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 46.06% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 59.01% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 24.57% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 20.09% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: vhl-1 (ok161) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 72.2% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: vhl-1 (ok161) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 68.53% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Gene Intervention: vhl-1 (ok161) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 51.6% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Gene Intervention: vhl-1 (ok161) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 49.38% (significant)
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Lifespan Observation Caenorhabditis elegans (N2) hermaphrodite
  • Gene Intervention: hif-1 (ia04) deletion / null
  • Gene Intervention: vhl-1 (ok161) deletion / null
  • Environment Intervention: Dietary restriction
mean lifespan increased 29.95% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: TOR1 deletion / null
mean lifespan increased 21.28% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: TOR1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 20.43% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 20.85% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 12.79% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SCH9 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 15.5% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SCH9 deletion / null
mean lifespan increased 41.86% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SCH9 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 116.18% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
mean lifespan increased 2.45%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: TOR1 deletion / null
mean lifespan increased 33.47% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: SCH9 deletion / null
mean lifespan increased 49.39% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: rho0
mean lifespan increased 3.85%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: rho0
  • Environment Intervention: dietary restriction
mean lifespan increased 29.49% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 29.49% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Environment Intervention: rho0
mean lifespan decreased -42.79% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Environment Intervention: rho0
  • Environment Intervention: dietary restriction
mean lifespan increased 22.07% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 42.79% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Gene Intervention: CYT1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 35.85% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 52.36% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Gene Intervention: CYT1 deletion / null
mean lifespan increased 2.83%
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Gene Intervention: CYT1 deletion / null
  • Environment Intervention: rho0
mean lifespan decreased -45.28% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Gene Intervention: CYT1 deletion / null
  • Environment Intervention: rho0
  • Environment Intervention: dietary restriction
mean lifespan increased 14.62% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Gene Intervention: CYT1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 15% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Gene Intervention: CYT1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 45% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Environment Intervention: rho0
  • Environment Intervention: dietary restriction
mean lifespan increased 83.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (PSY316AUT) matalpha
  • Environment Intervention: rho0
  • Environment Intervention: dietary restriction
mean lifespan increased 133.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
  • Environment Intervention: dietary restriction
mean lifespan increased 25.27% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 61.17% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
mean lifespan increased 1.1%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
mean lifespan increased 0.73%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
lifespan increased 2.83%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
lifespan increased 26.72% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
lifespan increased 70.45% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
lifespan increased 76.52% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HXK2 deletion / null
lifespan increased 70.82% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
lifespan increased 5.06%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: HXK2 deletion / null
lifespan increased 24.12% (significant)
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Lifespan Observation Saccharomyces cerevisiae (W303AR5 ) mata
  • Environment Intervention: dietary restriction
lifespan decreased -34.15% (significant)
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Lifespan Observation Saccharomyces cerevisiae (W303AR5 ) mata
  • Environment Intervention: dietary restriction
lifespan decreased -23.17% (significant)
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Lifespan Observation Saccharomyces cerevisiae (W303AR5 ) mata
  • Environment Intervention: dietary restriction
lifespan decreased -8.13% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 10.34% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan increased 19.54% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Environment Intervention: dietary restriction
mean lifespan decreased -11.49% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 17.62% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 68.2% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 57.09% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
  • Environment Intervention: dietary restriction
mean lifespan increased 31.03% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 53.64% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 75.86% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST3 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 15.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 76.63% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 19.92% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 61.3% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 67.05% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 29.89% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Compound Intervention: nicotinamide (5 millimolar)
  • Environment Intervention: dietary restriction
mean lifespan increased 2.3%
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: FOB1 deletion / null
  • Gene Intervention: SIR2 deletion / null
  • Gene Intervention: HST1 deletion / null
  • Gene Intervention: HST2 deletion / null
  • Gene Intervention: HST4 deletion / null
  • Gene Intervention: HST3 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan decreased -75.1% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: TOR1 deletion / null
  • Gene Intervention: GCN4 deletion / null
mean lifespan increased 48.72% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: TOR1 deletion / null
mean lifespan increased 56.41% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: GCN4 deletion / null
mean lifespan increased 11.97% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SCH9 deletion / null
  • Gene Intervention: GCN4 deletion / null
mean lifespan increased 38.84% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742 ) matalpha
  • Gene Intervention: SCH9 deletion / null
mean lifespan increased 49.59% (significant)
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