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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (0.75 µM)
  • Compound Intervention: ascr#3 (0.75 µM)
mean lifespan increased 12.5% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (01.25 µM)
  • Compound Intervention: ascr#3 (1.25 µM)
mean lifespan increased 22.62% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (1 µM)
  • Compound Intervention: ascr#3 (1 µM)
mean lifespan increased 14.89% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (4 nM)
mean lifespan increased 9.85% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan increased 14.39% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#3 (0.04 nM)
mean lifespan increased 10.61% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#3 (4 nM)
mean lifespan increased 12.88% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#3 (400 nM)
mean lifespan increased 21.21% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Gene Intervention: sir-2.1 (ok434) loss of function
  • Compound Intervention: ascr#2 (4 nM)
mean lifespan decreased -5.6%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Gene Intervention: sir-2.1 (ok434) loss of function
  • Compound Intervention: ascr#2 (0.04 nM)
mean lifespan decreased -4%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Gene Intervention: sir-2.1 (ok434) loss of function
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan decreased -5.6%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Gene Intervention: sir-2.1 (ok434) loss of function
  • Compound Intervention: ascr#3 (400 nM)
mean lifespan decreased -4.8%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Gene Intervention: sir-2.1 (ok434) loss of function
  • Compound Intervention: ascr#3 (4 nM)
mean lifespan increased 3.2%
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Lifespan Observation Caenorhabditis elegans (N2)
  • Gene Intervention: sir-2.1 (ok434) loss of function
  • Compound Intervention: ascr#3 (0.04 nM)
mean lifespan decreased -3.2%
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Lifespan Observation Caenorhabditis elegans (sir-2.1 (N3908))
  • Compound Intervention: ascr#2 (0.04 nM)
mean lifespan increased 8.33%
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Lifespan Observation Caenorhabditis elegans (sir-2.1 (N3908))
  • Compound Intervention: ascr#2 (4 nM)
mean lifespan increased 10.83%
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Lifespan Observation Caenorhabditis elegans (sir-2.1 (N3908))
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan increased 26.67%
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Lifespan Observation Caenorhabditis elegans (sir-2.1 OE (NL3909); daf-16(mgDf50))
  • Compound Intervention: ascr#2 (0.04 nM)
mean lifespan increased 16.35%
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Lifespan Observation Caenorhabditis elegans (sir-2.1 OE (NL3909); daf-16(mgDf50))
  • Compound Intervention: ascr#2 (4 nM)
mean lifespan increased 18.27% (significant)
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Lifespan Observation Caenorhabditis elegans (sir-2.1 OE (NL3909); daf-16(mgDf50))
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan increased 21.15% (significant)
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Lifespan Observation Caenorhabditis elegans (sir-2.1 OE (NL3909); daf-16(mgDf50))
  • Compound Intervention: ascr#3 (0.04 nM)
mean lifespan increased 14.42% (significant)
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Lifespan Observation Caenorhabditis elegans (sir-2.1 OE (NL3909); daf-16(mgDf50))
  • Compound Intervention: ascr#3 (4 nM)
mean lifespan increased 16.35% (significant)
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Lifespan Observation Caenorhabditis elegans (sir-2.1 OE (NL3909); daf-16(mgDf50))
  • Compound Intervention: ascr#3 (400 nM)
mean lifespan increased 14.42% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#2 (0.04 nM)
mean lifespan increased 8.65%
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#2 (4 nM)
mean lifespan increased 12.5% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#2 (4 nM)
mean lifespan increased 9.49% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#2 (40 nM)
mean lifespan increased 2.19%
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan increased 11.68% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#3 (4 nM)
mean lifespan increased 8.76% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#3 (40 nM)
mean lifespan increased 8.76% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-16 (mu86))
  • Compound Intervention: ascr#3 (400 nM)
mean lifespan increased 5.11%
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Lifespan Observation Caenorhabditis elegans (daf-12 (rh411rh61))
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan increased 8.74%
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Lifespan Observation Caenorhabditis elegans (daf-12 (rh411rh61))
  • Compound Intervention: ascr#3 (400 nM)
mean lifespan increased 9.71%
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Lifespan Observation Caenorhabditis elegans (daf-12 (rh411rh61))
  • Compound Intervention: ascr#2 (400 nM)
mean lifespan increased 8.49% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-12 (rh411rh61))
  • Compound Intervention: ascr#3 (400 nM)
mean lifespan increased 18.87%
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Lifespan Observation Caenorhabditis elegans (daf-2 (e1368))
  • Compound Intervention: ascr#2 (400 nM)
lifespan increased 7.57%
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Lifespan Observation Caenorhabditis elegans (daf-2 (e1368))
  • Compound Intervention: ascr#3 (400 nM)
lifespan increased 9.19%
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Lifespan Observation Caenorhabditis elegans (daf-7(e1372);daf-3(e1376))
  • Compound Intervention: ascr#2 (400 nM)
lifespan increased 9.09%
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Lifespan Observation Caenorhabditis elegans (daf-7(e1372);daf-3(e1376))
  • Compound Intervention: ascr#3 (400 nM)
lifespan increased 12.99% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-7(e1372);daf-3(e1376))
  • Compound Intervention: ascr#2 (400 nM)
lifespan increased 18.24% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-7(e1372);daf-3(e1376))
  • Compound Intervention: ascr#3 (400 nM)
lifespan increased 25% (significant)
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Lifespan Observation Caenorhabditis elegans (daf-37 OE)
  • Compound Intervention: ascr#2 (400 nM)
lifespan increased 18.87% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (200 nM)
  • Environment Intervention: Heat stress
mean lifespan increased 13.46% (significant)
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Lifespan Observation Caenorhabditis elegans (N2)
  • Compound Intervention: ascr#2 (400 nM)
  • Environment Intervention: Heat stress
mean lifespan increased 18.13% (significant)
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Lifespan Observation Caenorhabditis elegans (sir-2.1(ok434))
  • Compound Intervention: ascr#2 (200 nM)
  • Environment Intervention: Heat stress
mean lifespan decreased -6.74%
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Lifespan Observation Caenorhabditis elegans (sir-2.1(ok434))
  • Compound Intervention: ascr#2 (400 nM)
  • Environment Intervention: Heat stress
mean lifespan decreased -5.6%
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