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Lifespan Observation Saccharomyces cerevisiae (124) mata
  • Gene Intervention: CDC24 (cdc24-1) loss of function
  • Environment Intervention: temperature
mean lifespan decreased -8.33%
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Lifespan Observation Saccharomyces cerevisiae (182-6-3) mata
  • Gene Intervention: CDC7 (cdc7-1) loss of function
  • Environment Intervention: temperature
mean lifespan decreased -30.77% (significant)
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Lifespan Observation Saccharomyces cerevisiae (X2180-1A) mata
  • Environment Intervention: population enriched for 17-18 generation-old cells
mean lifespan decreased (significant)
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Lifespan Observation Saccharomyces cerevisiae (X2180-1A) mata
  • Gene Intervention: X2180-1B
mean lifespan increased 133.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (X2180-1A) mata
  • Gene Intervention: X2180-1A x X2180-1B
mean lifespan increased 108.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (X2180-1A) mata
  • Gene Intervention: X2180-1B
max lifespan increased 286.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (X2180-1A) mata
  • Gene Intervention: X2180-1A x X2180-1B
max lifespan increased 206.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (124) mata
  • Gene Intervention: CDC24 (cdc24-1) loss of function
  • Environment Intervention: temperature
mean lifespan decreased -8.33%
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Lifespan Observation Saccharomyces cerevisiae (182-6-3) mata
  • Gene Intervention: CDC7 (cdc7-1) loss of function
  • Environment Intervention: temperature
mean lifespan decreased -30.77% (significant)
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Lifespan Observation Saccharomyces cerevisiae (X2180-1A) mata
  • Environment Intervention: population enriched for 17-18 generation-old cells
mean lifespan decreased (significant)
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Lifespan Observation Saccharomyces cerevisiae (UCC519) matalpha
  • Environment Intervention: population enriched for 3 generation-old cells
median lifespan decreased -16.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (UCC519) matalpha
  • Environment Intervention: population enriched for 3 generation-old cells
median lifespan decreased -44.44% (significant)
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Lifespan Observation Saccharomyces cerevisiae (UCC519) matalpha
  • Environment Intervention: population enriched for 3 generation-old cells
median lifespan decreased -77.78% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: LAG1 deletion / null
  • Gene Intervention: LAG1 (pLAG416[pLAG1::LAG1]) normal
mean lifespan decreased -9.81%
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: LAG1 deletion / null
  • Gene Intervention: LAG1Hs (pMZ207[pLAG1::LAG1Hs]) normal
mean lifespan decreased -23.36% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 73.95% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RPD3 deletion / null
mean lifespan increased 103.36% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RPD3 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 97.48% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 139.5% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RPD3 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 142.86% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
  • Environment Intervention: dietary restriction
mean lifespan increased 157.98% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RPD3 deletion / null
  • Environment Intervention: dietary restriction
  • Environment Intervention: dietary restriction
mean lifespan increased 78.99% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 59.4% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HDA1 deletion / null
mean lifespan decreased -7.52%
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HDA1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 106.77% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 83.46% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HDA1 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 106.77% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
  • Environment Intervention: dietary restriction
mean lifespan increased 98.5% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HDA1 deletion / null
  • Environment Intervention: dietary restriction
  • Environment Intervention: dietary restriction
mean lifespan increased 102.26% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 32% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: SIR2 deletion / null
mean lifespan decreased -46.4% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan decreased -27.2% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 102.29% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: SIR2 deletion / null
mean lifespan decreased -37.4% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: SIR2 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan decreased -16.03% (significant)
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Lifespan Observation Saccharomyces cerevisiae (CS16) mata
  • Gene Intervention: ATP2 (G325A) loss of function
  • Environment Intervention: temperature
mean lifespan decreased -4.32% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: temperature
mean lifespan increased 34.09% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: PHB1 deletion / null
mean lifespan decreased -3.54%
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: PHB2 deletion / null
mean lifespan decreased -3.54%
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: PHB1 deletion / null
  • Gene Intervention: PHB2 deletion / null
mean lifespan decreased -4.55%
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
mean lifespan increased 31.14% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
  • Gene Intervention: PHB1 deletion / null
mean lifespan decreased -31.74% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
  • Gene Intervention: PHB2 deletion / null
mean lifespan decreased -31.14% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
  • Gene Intervention: PHB1 deletion / null
  • Gene Intervention: PHB2 deletion / null
mean lifespan decreased -58.08% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RAS2 deletion / null
mean lifespan decreased -20.75% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: RAS2 deletion / null
  • Gene Intervention: PHB1 deletion / null
mean lifespan decreased -30.66% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
mean lifespan decreased -18.4% (significant)
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Lifespan Observation Saccharomyces cerevisiae (rho0 ras2) mata
  • Gene Intervention: PHB1 deletion / null
mean lifespan decreased -7.66%
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Lifespan Observation Saccharomyces cerevisiae (rho0 ras2) mata
  • Gene Intervention: PHB2 deletion / null
mean lifespan decreased -11.48% (significant)
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Lifespan Observation Saccharomyces cerevisiae (rho0 ras2) mata
  • Gene Intervention: PHB1 deletion / null
  • Gene Intervention: PHB2 deletion / null
mean lifespan decreased -7.66%
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Lifespan Observation Saccharomyces cerevisiae (YJJ30) mata
  • Gene Intervention: LAG1 deletion / null
  • Gene Intervention: LAC1 deletion / null
  • Gene Intervention: LAG1 (pLAG416[LAG1]) normal
mean lifespan decreased -7.36%
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Lifespan Observation Saccharomyces cerevisiae (YJJ30) mata
  • Gene Intervention: LAG1 deletion / null
  • Gene Intervention: LAC1 deletion / null
  • Gene Intervention: YPC1 (pPK183[YPC1]) over-expression
mean lifespan decreased -22.94% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YJJ30) mata
  • Gene Intervention: LAG1 deletion / null
  • Gene Intervention: LAC1 deletion / null
  • Gene Intervention: YDC1 (pJJ26[YDC1]) over-expression
mean lifespan decreased -41.13% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: LAC1 deletion / null
mean lifespan increased 8.19%
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Lifespan Observation Saccharomyces cerevisiae (YJJ46) mata
  • Gene Intervention: YPC1 (pPK183[YPC1]) over-expression
mean lifespan increased 2.87%
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Lifespan Observation Saccharomyces cerevisiae (YJJ44) mata
  • Gene Intervention: LAG1 (pPB5[LAG1]) over-expression
mean lifespan increased 27.38% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YJJ45) mata
  • Gene Intervention: LAG1 (pPB5[LAG1]) over-expression
  • Compound Intervention: Galactose (0.0001)
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Lifespan Observation Saccharomyces cerevisiae (YJJ45) mata
  • Gene Intervention: LAG1 (pPB5[LAG1]) over-expression
  • Compound Intervention: Galactose (0.0005)
mean lifespan increased (significant)
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Lifespan Observation Saccharomyces cerevisiae (YJJ45) mata
  • Gene Intervention: LAG1 (pPB5[LAG1]) over-expression
  • Compound Intervention: Galactose (0.001)
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Lifespan Observation Saccharomyces cerevisiae (YJJ45) mata
  • Gene Intervention: LAG1 (pPB5[LAG1]) over-expression
  • Compound Intervention: Galactose (0.002)
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Lifespan Observation Saccharomyces cerevisiae (YJJ45) mata
  • Gene Intervention: LAG1 (pPB5[LAG1]) over-expression
  • Compound Intervention: Galactose (0.005)
mean lifespan decreased (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
mean lifespan increased 20.69% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: rho0 deletion / null
  • Gene Intervention: GCN5 deletion / null
mean lifespan decreased -38.42% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: GCN5 deletion / null
mean lifespan decreased -20.59% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: ELO3 deletion / null
mean lifespan decreased -18.15% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: KCS1 deletion / null
mean lifespan decreased -52.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: ELO3 deletion / null
  • Gene Intervention: KCS1 deletion / null
mean lifespan decreased -6.05%
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: ELO3 deletion / null
lifespan decreased (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: ELO3 deletion / null
  • Gene Intervention: IPK2 deletion / null
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Lifespan Observation Saccharomyces cerevisiae (BY4742) matalpha
  • Gene Intervention: ELO3 deletion / null
  • Gene Intervention: KCS1 deletion / null
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 64.29% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Environment Intervention: dietary restriction
mean lifespan increased 114.29% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HAP4 deletion / null
mean lifespan decreased -7.14%
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HAP4 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 14.29% (significant)
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Lifespan Observation Saccharomyces cerevisiae (YPK9) mata
  • Gene Intervention: HAP4 deletion / null
  • Environment Intervention: dietary restriction
mean lifespan increased 42.86% (significant)
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