Lifespan Observations Database

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Species:
M. musculus

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Lifespan Effect:
decreased (61)
increased (101)

Strain:
(C3H/HeJ x DW/J)F1 (1)
129 SvEv (2)
129Ola and BalbC (1)
129Sv and C57BL/6 mixed (4)
129Sv/J (1)
129Sv/J × Balb/c (1)
129SvEv-C57BL/6 mixed genetic background (1)
AKR/J (2)
Brca1Δ11/Δ11 p53 +/− (1)
C3H/Sn (2)
C57BL/6 (6)
C57BL/6J (10)
C57BL/6J and C3H/J mixed background (1)
C57BL6 (2)
CByB6F1 (2)
CD-1 (1)
FVB (1)
HER-2/neu (5)
heterogeneous genetic background (2)
ICR/CD-1 (1)
Jc1:ICR (2)
Line A1 (2)
Line A2 (2)
Mixed 129/Sv and C57BL6 (1)
Mixed background (B6;129P2OlaHsd) (4)
Mixed genetic background (1)
mixed genetic background of C57BL/6 and 129SvEv (2)
R722W/R722W (1)
SHR (12)
Swiss (1)
UM-HET3 (30)
wild (2)
WW6/C57BL/6 (1)
Zmpste24-/- (1)

Mating Type:
female (46)
male (42)

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Showing results 1 - 100 of 176:


	Mus musculus (129 SvEv) Gene Intervention: p66shc (heterzygous) deletion / null median lifespan increased 7.1% (significant)	more >
	Mus musculus ((C3H/HeJ x DW/J)F1) Gene Intervention: Pit1 non-null recessive lifespan increased (significant)	more >
	Mus musculus (FVB) Gene Intervention: Plau over-expression lifespan increased (significant)	more >
	Mus musculus (Mixed genetic background) Gene Intervention: Terc deletion / null lifespan decreased (significant)	more >
	Mus musculus (C57BL/6J) Gene Intervention: MsrA deletion / null lifespan decreased (significant)	more >
	Mus musculus (R722W/R722W) Gene Intervention: XPD non-null recessive lifespan decreased (significant)	more >
	Mus musculus (129Ola and BalbC) Gene Intervention: GHR deletion / null lifespan increased (significant)	more >
	Mus musculus Gene Intervention: Insr deletion / null lifespan increased (significant)	more >
	Mus musculus Gene Intervention: Adcy5 deletion / null lifespan increased 30% (significant)	more >
	Mus musculus Gene Intervention: Arhgap1 deletion / null lifespan increased 50% (significant)	more >
	Mus musculus Gene Intervention: bax deletion / null	more >
	Mus musculus (C57BL/6) Compound Intervention: rapamycin (4 mg/kg every other day) median lifespan increased 13.54% (significant)	more >
	Mus musculus Gene Intervention: Igf1 over-expression lifespan increased 23% (significant)	more >
	Mus musculus Gene Intervention: Pck1 over-expression lifespan increased 33% (significant)	more >
	Mus musculus Gene Intervention: Plau over-expression lifespan increased 20% (significant)	more >
	Mus musculus Gene Intervention: Terf2 over-expression lifespan decreased (significant)	more >
	Mus musculus Gene Intervention: Tert over-expression lifespan increased (significant)	more >
	Mus musculus Gene Intervention: Txn1 over-expression lifespan increased 35% (significant)	more >
	Mus musculus Gene Intervention: Ucp2 over-expression lifespan increased 12% (significant)	more >
	Mus musculus Gene Intervention: Ucp2 over-expression lifespan increased 20% (significant)	more >
	Mus musculus Gene Intervention: Zdhhc13 loss of function median lifespan decreased (significant)	more >
	Mus musculus female Gene Intervention: Pparg (P465L) non-null dominant Gene Intervention: Ins2 (Akita) unknown median lifespan decreased (significant)	more >
	Mus musculus (129 SvEv) Gene Intervention: p66shc (homozygous) deletion / null median lifespan increased 27.86% (significant)	more >
	Mus musculus (AKR/J) Environment Intervention: irradiation lifespan increased 5.65% (significant)	more >
	Mus musculus (AKR/J) Environment Intervention: irradiation lifespan decreased -9.57% (significant)	more >
	Mus musculus male Gene Intervention: CEBPA deletion / null Gene Intervention: CEBPB over-expression mean lifespan increased 21.94% (significant)	more >
	Mus musculus Gene Intervention: Arntl deletion / null lifespan decreased -64.52% (significant)	more >
	Mus musculus Gene Intervention: Arntl deletion / null lifespan decreased -64.52% (significant)	more >
	Mus musculus (WW6/C57BL/6) Gene Intervention: Atm deletion / null mean lifespan decreased -37.5% (significant)	more >
	Mus musculus (Brca1Δ11/Δ11 p53 +/−) Gene Intervention: Brca1 deletion / null mean lifespan decreased -25% (significant)	more >
	Mus musculus Gene Intervention: Bub1b loss of function mean lifespan decreased -60% (significant)	more >
	Mus musculus Gene Intervention: Bub3 loss of function Gene Intervention: Rae1 loss of function lifespan increased 12% (significant)	more >
	Mus musculus Gene Intervention: Bub3 loss of function	more >
	Mus musculus Gene Intervention: Rae1 loss of function mean lifespan decreased -8.33%	more >
	Mus musculus Gene Intervention: Casp2 loss of function max lifespan decreased -9.33% (significant)	more >
	Mus musculus Gene Intervention: cat over-expression lifespan increased 20% (significant)	more >
	Mus musculus Gene Intervention: cav1 loss of function mean lifespan decreased -50% (significant)	more >
	Mus musculus Gene Intervention: Cdkn1a deletion / null mean lifespan increased 33.33% (significant)	more >
	Mus musculus (Zmpste24-/-) Compound Intervention: Recombinant human IGF-1 (1 mg/kg/day) median lifespan increased 16.67% (significant)	more >
	Mus musculus female Gene Intervention: Chk2 loss of function mean lifespan increased 240% (significant)	more >
	Mus musculus (129Sv/J) Gene Intervention: clk-1 loss of function mean lifespan increased 14.44% (significant)	more >
	Mus musculus (129Sv/J × Balb/c ) Gene Intervention: clk-1 loss of function mean lifespan increased 30.67% (significant)	more >
	Mus musculus (C57BL/6) male Gene Intervention: Prkar2b deletion / null median lifespan increased 13.69% (significant)	more >
	Mus musculus (C57BL/6) female Gene Intervention: Prkar2b deletion / null median lifespan decreased -2.41%	more >
	Mus musculus (UM-HET3) female Environment Intervention: Dietary restriction mean lifespan increased 39.83% (significant)	more >
	Mus musculus (UM-HET3) male Environment Intervention: Dietary restriction mean lifespan increased 32.49% (significant)	more >
	Mus musculus (CByB6F1) male Environment Intervention: Dietary restriction mean lifespan increased 37.54% (significant)	more >
	Mus musculus (CByB6F1) female Environment Intervention: Dietary restriction mean lifespan increased 28.17% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water)	more >
	Mus musculus (UM-HET3) female Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water)	more >
	Mus musculus (UM-HET3) male Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water) median lifespan increased 12.2% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water) median lifespan increased 21.95% (significant)	more >
	Mus musculus (ICR/CD-1) female Environment Intervention: Environmental enrichment median lifespan increased 6.52% (significant)	more >
	Mus musculus (heterogeneous genetic background) male Gene Intervention: Prop1 (df) loss of function median lifespan increased 48.64% (significant)	more >
	Mus musculus (heterogeneous genetic background) male Gene Intervention: Prop1 (df) loss of function Compound Intervention: porcine growth hormone (4 micrograms/g body weight per day) median lifespan increased 6.48%	more >
	Mus musculus (Jc1:ICR) male Environment Intervention: High polyamine diet median lifespan increased 23.81% (significant)	more >
	Mus musculus (Jc1:ICR) male Environment Intervention: Low polyamine diet median lifespan increased 3.81%	more >
	Mus musculus (Mixed 129/Sv and C57BL6) Gene Intervention: huntingtin (deltaQ-htt) unknown median lifespan increased 18.03% (significant)	more >
	Mus musculus Gene Intervention: Zmpste24 deletion / null mean lifespan decreased -55% (significant)	more >
	Mus musculus Gene Intervention: TRp63 loss of function median lifespan decreased -21.49% (significant)	more >
	Mus musculus Gene Intervention: Trp53 loss of function lifespan increased 23% (significant)	more >
	Mus musculus Gene Intervention: Efemp1 loss of function median lifespan decreased -19.13% (significant)	more >
	Mus musculus Gene Intervention: Efemp1 loss of function max lifespan decreased -28.82% (significant)	more >
	Mus musculus Gene Intervention: fgf23 loss of function mean lifespan decreased -66.67% (significant)	more >
	Mus musculus Gene Intervention: fxn loss of function mean lifespan decreased -75% (significant)	more >
	Mus musculus male Gene Intervention: GH1 gain of function mean lifespan decreased -48.75% (significant)	more >
	Mus musculus (C57BL/6J) male Gene Intervention: GHA loss of function median lifespan increased 18.07% (significant)	more >
	Mus musculus (C57BL/6J) female Gene Intervention: GHA loss of function median lifespan increased 32.86% (significant)	more >
	Mus musculus (C57BL/6J) male Gene Intervention: Ghrhr loss of function lifespan increased 23.36% (significant)	more >
	Mus musculus (C57BL/6J) female Gene Intervention: Ghrhr loss of function lifespan increased 24.85% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: rapamycin (2.24 mg/kg/day) median lifespan increased 5.13% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: rapamycin (2.24 mg/kg/day) median lifespan increased 9.52% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: rapamycin (2.24 mg/kg/day) median lifespan increased 13.85% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: rapamycin (2.24 mg/kg/day) median lifespan increased 21.15% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: rapamycin (2.24 mg/kg/day) median lifespan increased 13.13% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: rapamycin (2.24 mg/kg/day) median lifespan increased 19.34% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: resveratrol (300 mg/kg/day)	more >
	Mus musculus (UM-HET3) male Compound Intervention: resveratrol (300 mg/kg/day)	more >
	Mus musculus (UM-HET3) male Compound Intervention: resveratrol (1200 mg/kg/day)	more >
	Mus musculus (UM-HET3) female Compound Intervention: resveratrol (1200 mg/kg/day)	more >
	Mus musculus (UM-HET3) female Compound Intervention: simvastatin (120 mg/kg/day)	more >
	Mus musculus (UM-HET3) male Compound Intervention: simvastatin (120 mg/kg/day)	more >
	Mus musculus (UM-HET3) male Compound Intervention: simvastatin (12 mg/kg/day)	more >
	Mus musculus (UM-HET3) female Compound Intervention: simvastatin (12 mg/kg/day)	more >
	Mus musculus (UM-HET3) female Compound Intervention: rapamycin (2.24 mg/kg/day) mean lifespan increased 15% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: rapamycin (2.24 mg/kg/day) mean lifespan increased 16% (significant)	more >
	Mus musculus (UM-HET3) female Compound Intervention: rapamycin (2.24 mg/kg/day) mean lifespan increased 7% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: rapamycin (2.24 mg/kg/day) mean lifespan increased 5% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: rapamycin (2.24 mg/kg/day) mean lifespan increased 8% (significant)	more >
	Mus musculus (UM-HET3) male Compound Intervention: rapamycin (2.24 mg/kg/day) mean lifespan increased 15% (significant)	more >
	Mus musculus (C3H/Sn) female Compound Intervention: phenformin (5 mg/mouse 5 treatments/week) mean lifespan increased 21.11% (significant)	more >
	Mus musculus (C3H/Sn) female Compound Intervention: phenformin (5 mg/mouse 5 treatments/week) max lifespan increased 28.37% (significant)	more >
	Mus musculus (HER-2/neu) female Compound Intervention: metformin (100 mg/kg 5 doses/week) mean lifespan increased 6.67%	more >
	Mus musculus (HER-2/neu) female Compound Intervention: metformin (100 mg/kg 5 doses/week) max lifespan decreased -11.11% (significant)	more >
	Mus musculus (HER-2/neu) female Compound Intervention: metformin (100 mg/kg 5 doses/week) max lifespan decreased -11.11% (significant)	more >
	Mus musculus (HER-2/neu) female Compound Intervention: metformin (100 mg/kg 5 doses/week) max lifespan increased 13.13% (significant)	more >
	Mus musculus (HER-2/neu) female Compound Intervention: metformin (100 mg/kg 5 doses/week) mean lifespan increased 7.95% (significant)	more >
	Mus musculus (C57BL/6J) Gene Intervention: AIMP3 over-expression median lifespan decreased -50% (significant)	more >
	Mus musculus (129SvEv-C57BL/6 mixed genetic background) Gene Intervention: Top3b deletion / null mean lifespan decreased -37.5% (significant)	more >
	Mus musculus Gene Intervention: Surf1 loss of function median lifespan increased 21.25% (significant)	more >

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