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Showing results 1 - 100 of 176:
Lifespan Observation Mus musculus (129 SvEv)
  • Gene Intervention: p66shc (heterzygous) deletion / null
median lifespan increased 7.1% (significant)
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Lifespan Observation Mus musculus ((C3H/HeJ x DW/J)F1)
  • Gene Intervention: Pit1 non-null recessive
lifespan increased (significant)
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Lifespan Observation Mus musculus (FVB)
  • Gene Intervention: Plau over-expression
lifespan increased (significant)
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Lifespan Observation Mus musculus (Mixed genetic background)
  • Gene Intervention: Terc deletion / null
lifespan decreased (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: MsrA deletion / null
lifespan decreased (significant)
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Lifespan Observation Mus musculus (R722W/R722W)
  • Gene Intervention: XPD non-null recessive
lifespan decreased (significant)
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Lifespan Observation Mus musculus (129Ola and BalbC)
  • Gene Intervention: GHR deletion / null
lifespan increased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Insr deletion / null
lifespan increased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Adcy5 deletion / null
lifespan increased 30% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Arhgap1 deletion / null
lifespan increased 50% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: bax deletion / null
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Lifespan Observation Mus musculus (C57BL/6)
  • Compound Intervention: rapamycin (4 mg/kg every other day)
median lifespan increased 13.54% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Igf1 over-expression
lifespan increased 23% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Pck1 over-expression
lifespan increased 33% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Plau over-expression
lifespan increased 20% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Terf2 over-expression
lifespan decreased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Tert over-expression
lifespan increased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Txn1 over-expression
lifespan increased 35% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Ucp2 over-expression
lifespan increased 12% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Ucp2 over-expression
lifespan increased 20% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Zdhhc13 loss of function
median lifespan decreased (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Pparg (P465L) non-null dominant
  • Gene Intervention: Ins2 (Akita) unknown
median lifespan decreased (significant)
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Lifespan Observation Mus musculus (129 SvEv)
  • Gene Intervention: p66shc (homozygous) deletion / null
median lifespan increased 27.86% (significant)
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Lifespan Observation Mus musculus (AKR/J)
  • Environment Intervention: irradiation
lifespan increased 5.65% (significant)
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Lifespan Observation Mus musculus (AKR/J)
  • Environment Intervention: irradiation
lifespan decreased -9.57% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: CEBPA deletion / null
  • Gene Intervention: CEBPB over-expression
mean lifespan increased 21.94% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Arntl deletion / null
lifespan decreased -64.52% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Arntl deletion / null
lifespan decreased -64.52% (significant)
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Lifespan Observation Mus musculus (WW6/C57BL/6)
  • Gene Intervention: Atm deletion / null
mean lifespan decreased -37.5% (significant)
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Lifespan Observation Mus musculus (Brca1Δ11/Δ11 p53 +/−)
  • Gene Intervention: Brca1 deletion / null
mean lifespan decreased -25% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Bub1b loss of function
mean lifespan decreased -60% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Bub3 loss of function
  • Gene Intervention: Rae1 loss of function
lifespan increased 12% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Bub3 loss of function
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Lifespan Observation Mus musculus
  • Gene Intervention: Rae1 loss of function
mean lifespan decreased -8.33%
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Lifespan Observation Mus musculus
  • Gene Intervention: Casp2 loss of function
max lifespan decreased -9.33% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: cat over-expression
lifespan increased 20% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: cav1 loss of function
mean lifespan decreased -50% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Cdkn1a deletion / null
mean lifespan increased 33.33% (significant)
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Lifespan Observation Mus musculus (Zmpste24-/-)
  • Compound Intervention: Recombinant human IGF-1 (1 mg/kg/day)
median lifespan increased 16.67% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Chk2 loss of function
mean lifespan increased 240% (significant)
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Lifespan Observation Mus musculus (129Sv/J)
  • Gene Intervention: clk-1 loss of function
mean lifespan increased 14.44% (significant)
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Lifespan Observation Mus musculus (129Sv/J × Balb/c )
  • Gene Intervention: clk-1 loss of function
mean lifespan increased 30.67% (significant)
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Lifespan Observation Mus musculus (C57BL/6) male
  • Gene Intervention: Prkar2b deletion / null
median lifespan increased 13.69% (significant)
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Lifespan Observation Mus musculus (C57BL/6) female
  • Gene Intervention: Prkar2b deletion / null
median lifespan decreased -2.41%
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Lifespan Observation Mus musculus (UM-HET3) female
  • Environment Intervention: Dietary restriction
mean lifespan increased 39.83% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Environment Intervention: Dietary restriction
mean lifespan increased 32.49% (significant)
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Lifespan Observation Mus musculus (CByB6F1) male
  • Environment Intervention: Dietary restriction
mean lifespan increased 37.54% (significant)
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Lifespan Observation Mus musculus (CByB6F1) female
  • Environment Intervention: Dietary restriction
mean lifespan increased 28.17% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water)
median lifespan increased 12.2% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water)
median lifespan increased 21.95% (significant)
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Lifespan Observation Mus musculus (ICR/CD-1) female
  • Environment Intervention: Environmental enrichment
median lifespan increased 6.52% (significant)
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Lifespan Observation Mus musculus (heterogeneous genetic background) male
  • Gene Intervention: Prop1 (df) loss of function
median lifespan increased 48.64% (significant)
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Lifespan Observation Mus musculus (heterogeneous genetic background) male
  • Gene Intervention: Prop1 (df) loss of function
  • Compound Intervention: porcine growth hormone (4 micrograms/g body weight per day)
median lifespan increased 6.48%
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Lifespan Observation Mus musculus (Jc1:ICR) male
  • Environment Intervention: High polyamine diet
median lifespan increased 23.81% (significant)
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Lifespan Observation Mus musculus (Jc1:ICR) male
  • Environment Intervention: Low polyamine diet
median lifespan increased 3.81%
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Lifespan Observation Mus musculus (Mixed 129/Sv and C57BL6)
  • Gene Intervention: huntingtin (deltaQ-htt) unknown
median lifespan increased 18.03% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Zmpste24 deletion / null
mean lifespan decreased -55% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: TRp63 loss of function
median lifespan decreased -21.49% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Trp53 loss of function
lifespan increased 23% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Efemp1 loss of function
median lifespan decreased -19.13% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Efemp1 loss of function
max lifespan decreased -28.82% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: fgf23 loss of function
mean lifespan decreased -66.67% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: fxn loss of function
mean lifespan decreased -75% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: GH1 gain of function
mean lifespan decreased -48.75% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) male
  • Gene Intervention: GHA loss of function
median lifespan increased 18.07% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) female
  • Gene Intervention: GHA loss of function
median lifespan increased 32.86% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) male
  • Gene Intervention: Ghrhr loss of function
lifespan increased 23.36% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) female
  • Gene Intervention: Ghrhr loss of function
lifespan increased 24.85% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 5.13% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 9.52% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 13.85% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 21.15% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 19.34% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: resveratrol (300 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: resveratrol (300 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: resveratrol (1200 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: resveratrol (1200 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: simvastatin (120 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: simvastatin (120 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: simvastatin (12 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: simvastatin (12 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 15% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 16% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 7% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 5% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 8% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 15% (significant)
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Lifespan Observation Mus musculus (C3H/Sn) female
  • Compound Intervention: phenformin (5 mg/mouse 5 treatments/week)
mean lifespan increased 21.11% (significant)
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Lifespan Observation Mus musculus (C3H/Sn) female
  • Compound Intervention: phenformin (5 mg/mouse 5 treatments/week)
max lifespan increased 28.37% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 6.67%
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 7.95% (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: AIMP3 over-expression
median lifespan decreased -50% (significant)
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Lifespan Observation Mus musculus (129SvEv-C57BL/6 mixed genetic background)
  • Gene Intervention: Top3b deletion / null
mean lifespan decreased -37.5% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Surf1 loss of function
median lifespan increased 21.25% (significant)
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