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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: rapamycin (0.55 nM)
median lifespan increased 20% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: caffeine (0.4 mM)
median lifespan increased 20% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: BRE5 deletion / null
mean lifespan increased 30% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: IDH2 deletion / null
mean lifespan increased 18% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: REI1 deletion / null
mean lifespan increased 47% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL31A deletion / null
mean lifespan increased 59% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL6B deletion / null
mean lifespan increased 33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TOR1 deletion / null
mean lifespan increased 22% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: URE2 deletion / null
mean lifespan increased 21% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: YBR238C deletion / null
mean lifespan increased 34% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: YBR255W deletion / null
mean lifespan increased 25% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: YBR266C deletion / null
mean lifespan increased 47% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: YOR135W deletion / null
mean lifespan increased 18% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TOR1 deletion / null
mean lifespan increased 25.3% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL31A deletion / null
mean lifespan increased 59.29% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL6B deletion / null
mean lifespan increased 32.41% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: YPT6 deletion / null
mean lifespan increased 10.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: YGR130C deletion / null
mean lifespan increased 19.2% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TIS11 deletion / null
mean lifespan increased 25.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: SIS2 deletion / null
mean lifespan increased 27.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: SAM1 deletion / null
mean lifespan increased 12.9% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: PMR1 deletion / null
mean lifespan increased 14.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: PKH2 deletion / null
mean lifespan increased 14.4% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: INP51 deletion / null
mean lifespan increased 10.6% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: IDH1 deletion / null
mean lifespan increased 9% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: HSE1 deletion / null
mean lifespan increased 13.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: DBP3 deletion / null
mean lifespan increased 21.5% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: ALG12 deletion / null
mean lifespan increased 23.8% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: ADH1 deletion / null
mean lifespan increased 14.9% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TOR1 deletion / null
mean lifespan increased 21.6% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TIF4631 deletion / null
mean lifespan increased 22.8% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TIF2 deletion / null
mean lifespan increased 14.9% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: TIF1 deletion / null
mean lifespan increased 14.6% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: SPT4 deletion / null
mean lifespan increased 38.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL9A deletion / null
mean lifespan increased 19.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL6B deletion / null
mean lifespan increased 32.7% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL19A deletion / null
mean lifespan increased 48.2% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: INP53 deletion / null
mean lifespan increased 10.2% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: IDH2 deletion / null
mean lifespan increased 16.9% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: AFG3 deletion / null
mean lifespan increased 21.4% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL22A deletion / null
mean lifespan increased 90.93% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL20B deletion / null
mean lifespan increased 80.99% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL21B deletion / null
mean lifespan increased 80.35% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL13A deletion / null
mean lifespan increased 60.91% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL31A deletion / null
mean lifespan increased 59.41% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL34B deletion / null
mean lifespan increased 58.1% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS12 deletion / null
mean lifespan increased 52.94% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL19A deletion / null
mean lifespan increased 48.16% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL39 deletion / null
mean lifespan increased 46.69% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPP2B deletion / null
mean lifespan increased 44.92% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL23A deletion / null
mean lifespan increased 40.54% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL29 deletion / null
mean lifespan increased 35.47% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL43B deletion / null
mean lifespan increased 32.88% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL6B deletion / null
mean lifespan increased 32.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL9B deletion / null
mean lifespan increased 31.76% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS11A deletion / null
mean lifespan increased 26.12% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL37B deletion / null
mean lifespan increased 18.14%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL7A deletion / null
mean lifespan increased 17.37% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL9A deletion / null
mean lifespan increased 15.37%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL17B deletion / null
mean lifespan increased 11.06%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL34A deletion / null
mean lifespan increased 10.35%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS17A deletion / null
mean lifespan increased 10.12%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL23B deletion / null
mean lifespan increased 10.12%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPP2A deletion / null
mean lifespan increased 8.28%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL12A deletion / null
mean lifespan increased 7.39%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL8B deletion / null
mean lifespan increased 4.87%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS21A deletion / null
mean lifespan increased 3.82%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS1A deletion / null
mean lifespan increased 2.77%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL20A deletion / null
mean lifespan increased 1.65%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL1B deletion / null
mean lifespan increased 1.17%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL12B deletion / null
mean lifespan decreased -0.42%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPP1B deletion / null
mean lifespan decreased -7.78%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS22B deletion / null
mean lifespan decreased -7.82%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL35B deletion / null
mean lifespan decreased -8.75%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL2B deletion / null
mean lifespan decreased -8.95%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL6A deletion / null
mean lifespan decreased -9.53%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL8A deletion / null
mean lifespan decreased -10.89%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL7B deletion / null
mean lifespan decreased -11.28%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL19B deletion / null
mean lifespan decreased -13.62%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL2A deletion / null
mean lifespan decreased -15.76%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPS29A deletion / null
mean lifespan decreased -18.8%
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPP1A deletion / null
mean lifespan decreased -29.41% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: RPL43A deletion / null
mean lifespan decreased -49.41% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: spermidine (4 mM)
median lifespan increased 233.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: spermidine (1 mM)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Compound Intervention: spermidine (4 mM)
median lifespan increased 100% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: iki3 deletion / null
  • Gene Intervention: sas3 deletion / null
  • Compound Intervention: spermidine (4 mM)
median lifespan increased 46.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: iki3 deletion / null
  • Gene Intervention: sas3 deletion / null
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: spe1 deletion / null
median lifespan decreased -50% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: spe1 deletion / null
  • Compound Intervention: spermidine (0.1 mM)
median lifespan decreased (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: vps36 deletion / null
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: vps25 deletion / null
median lifespan decreased -13.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: vps8 deletion / null
median lifespan decreased -33.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: vps27 deletion / null
median lifespan decreased -66.67% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: vps21 deletion / null
median lifespan decreased -33.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: abc1 deletion / null
median lifespan increased 113.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: trm9 deletion / null
median lifespan increased 100% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: aro7 deletion / null
median lifespan increased 133.33% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: cka2 deletion / null
median lifespan increased 100% (significant)
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Lifespan Observation Saccharomyces cerevisiae (BY4741) mata
  • Gene Intervention: ydr417c deletion / null
median lifespan increased 33.33% (significant)
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