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Showing results 1 - 42 of 42:
Lifespan Observation Mus musculus male
  • Gene Intervention: CEBPA deletion / null
  • Gene Intervention: CEBPB over-expression
mean lifespan increased 21.94% (significant)
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Lifespan Observation Mus musculus (C57BL/6) male
  • Gene Intervention: Prkar2b deletion / null
median lifespan increased 13.69% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Environment Intervention: Dietary restriction
mean lifespan increased 32.49% (significant)
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Lifespan Observation Mus musculus (CByB6F1) male
  • Environment Intervention: Dietary restriction
mean lifespan increased 37.54% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water)
median lifespan increased 12.2% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water)
median lifespan increased 21.95% (significant)
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Lifespan Observation Mus musculus (heterogeneous genetic background) male
  • Gene Intervention: Prop1 (df) loss of function
median lifespan increased 48.64% (significant)
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Lifespan Observation Mus musculus (heterogeneous genetic background) male
  • Gene Intervention: Prop1 (df) loss of function
  • Compound Intervention: porcine growth hormone (4 micrograms/g body weight per day)
median lifespan increased 6.48%
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Lifespan Observation Mus musculus (Jc1:ICR) male
  • Environment Intervention: High polyamine diet
median lifespan increased 23.81% (significant)
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Lifespan Observation Mus musculus (Jc1:ICR) male
  • Environment Intervention: Low polyamine diet
median lifespan increased 3.81%
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Lifespan Observation Mus musculus male
  • Gene Intervention: GH1 gain of function
mean lifespan decreased -48.75% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) male
  • Gene Intervention: GHA loss of function
median lifespan increased 18.07% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) male
  • Gene Intervention: Ghrhr loss of function
lifespan increased 23.36% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 5.13% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 9.52% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 13.85% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: resveratrol (300 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: resveratrol (1200 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: simvastatin (120 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: simvastatin (12 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 5% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 8% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 15% (significant)
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Lifespan Observation Mus musculus (mixed genetic background of C57BL/6 and 129SvEv) male
  • Gene Intervention: Chip loss of function
median lifespan decreased -68.8% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Igfr1 loss of function
lifespan increased 16.07% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Nos3 loss of function
mean lifespan decreased -12.5% (significant)
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) male
  • Gene Intervention: NAS1 (-/-) deletion / null
median lifespan increased 30% (significant)
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) male
  • Gene Intervention: NAS1 (+/-) deletion / null
median lifespan increased 5%
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Lifespan Observation Mus musculus male
  • Gene Intervention: Ppm1d loss of function
mean lifespan decreased -25% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Ppm1d loss of function
max lifespan decreased -24.69% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Prop1 loss of function
mean lifespan increased 48.82% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) male
  • Gene Intervention: PARP-1 (2xhPARP-1) over-expression
median lifespan decreased -21.71% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) male
  • Gene Intervention: PARP-1 (1xhPARP-1) over-expression
median lifespan decreased -0.75%
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Lifespan Observation Mus musculus (Line A1) male
  • Gene Intervention: Fox01 over-expression
mean lifespan increased 1.92% (significant)
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Lifespan Observation Mus musculus (Line A2) male
  • Gene Intervention: Fox01 over-expression
mean lifespan increased (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: nordihydroguaiaretic acid (NDGA) (417 mg/kg/day)
median lifespan increased 12.09% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: aspirin (3.3 mg/kg/day)
median lifespan increased 8.02% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Nas-1 deletion / null
median lifespan increased 25% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Nas-1 loss of function
median lifespan increased 4%
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Lifespan Observation Mus musculus male
  • Gene Intervention: lrs1 deletion / null
median lifespan increased 15.61% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: lrs1 deletion / null
mean lifespan increased 14.12% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: eIF-5A2 over-expression
mean lifespan decreased -66.67% (significant)
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