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Showing results 1 - 46 of 46:
Lifespan Observation Mus musculus female
  • Gene Intervention: Pparg (P465L) non-null dominant
  • Gene Intervention: Ins2 (Akita) unknown
median lifespan decreased (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Chk2 loss of function
mean lifespan increased 240% (significant)
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Lifespan Observation Mus musculus (C57BL/6) female
  • Gene Intervention: Prkar2b deletion / null
median lifespan decreased -2.41%
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Lifespan Observation Mus musculus (UM-HET3) female
  • Environment Intervention: Dietary restriction
mean lifespan increased 39.83% (significant)
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Lifespan Observation Mus musculus (CByB6F1) female
  • Environment Intervention: Dietary restriction
mean lifespan increased 28.17% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water)
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Lifespan Observation Mus musculus (ICR/CD-1) female
  • Environment Intervention: Environmental enrichment
median lifespan increased 6.52% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) female
  • Gene Intervention: GHA loss of function
median lifespan increased 32.86% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) female
  • Gene Intervention: Ghrhr loss of function
lifespan increased 24.85% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 21.15% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 19.34% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: resveratrol (300 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: resveratrol (1200 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: simvastatin (120 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: simvastatin (12 mg/kg/day)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 15% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 16% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 7% (significant)
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Lifespan Observation Mus musculus (C3H/Sn) female
  • Compound Intervention: phenformin (5 mg/mouse 5 treatments/week)
mean lifespan increased 21.11% (significant)
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Lifespan Observation Mus musculus (C3H/Sn) female
  • Compound Intervention: phenformin (5 mg/mouse 5 treatments/week)
max lifespan increased 28.37% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 6.67%
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 7.95% (significant)
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Lifespan Observation Mus musculus (mixed genetic background of C57BL/6 and 129SvEv) female
  • Gene Intervention: Chip loss of function
median lifespan decreased -55.2% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Igfr1 loss of function
lifespan increased 33.1% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Nos3 loss of function
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) female
  • Gene Intervention: NAS1 (+/-) deletion / null
median lifespan increased 17.65% (significant)
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) female
  • Gene Intervention: NAS1 (-/-) deletion / null
median lifespan increased 23.53% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Ppm1d loss of function
mean lifespan decreased -2.48%
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Lifespan Observation Mus musculus female
  • Gene Intervention: Ppm1d loss of function
max lifespan decreased -8.97%
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Lifespan Observation Mus musculus female
  • Gene Intervention: Prop1 loss of function
mean lifespan increased 67.97% (significant)
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Lifespan Observation Mus musculus (Swiss) female
  • Compound Intervention: 2,4-dinitrophenol (1 mg/L in drinking water)
mean lifespan increased 7.08% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) female
  • Gene Intervention: PARP-1 (1xhPARP-1) over-expression
median lifespan decreased -19.35% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) female
  • Gene Intervention: PARP-1 (2xhPARP-1) over-expression
median lifespan decreased -22.92% (significant)
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Lifespan Observation Mus musculus (Line A1) female
  • Gene Intervention: Fox01 over-expression
mean lifespan increased (significant)
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Lifespan Observation Mus musculus (Line A2) female
  • Gene Intervention: Fox01 over-expression
mean lifespan decreased (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: nordihydroguaiaretic acid (NDGA) (417 mg/kg/day)
median lifespan decreased -0.76%
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: aspirin (3.3 mg/kg/day)
median lifespan decreased -0.76%
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Lifespan Observation Mus musculus female
  • Gene Intervention: Nas-1 deletion / null
median lifespan increased 25% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Nas-1 loss of function
median lifespan increased 20% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: lrs1 deletion / null
mean lifespan increased 7.03% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: lrs1 deletion / null
median lifespan increased 10.14% (significant)
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