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Showing results 1 - 100 of 101:
Lifespan Observation Mus musculus (129 SvEv)
  • Gene Intervention: p66shc (heterzygous) deletion / null
median lifespan increased 7.1% (significant)
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Lifespan Observation Mus musculus ((C3H/HeJ x DW/J)F1)
  • Gene Intervention: Pit1 non-null recessive
lifespan increased (significant)
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Lifespan Observation Mus musculus (FVB)
  • Gene Intervention: Plau over-expression
lifespan increased (significant)
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Lifespan Observation Mus musculus (129Ola and BalbC)
  • Gene Intervention: GHR deletion / null
lifespan increased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Insr deletion / null
lifespan increased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Adcy5 deletion / null
lifespan increased 30% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Arhgap1 deletion / null
lifespan increased 50% (significant)
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Lifespan Observation Mus musculus (C57BL/6)
  • Compound Intervention: rapamycin (4 mg/kg every other day)
median lifespan increased 13.54% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Igf1 over-expression
lifespan increased 23% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Pck1 over-expression
lifespan increased 33% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Plau over-expression
lifespan increased 20% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Tert over-expression
lifespan increased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Txn1 over-expression
lifespan increased 35% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Ucp2 over-expression
lifespan increased 12% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Ucp2 over-expression
lifespan increased 20% (significant)
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Lifespan Observation Mus musculus (129 SvEv)
  • Gene Intervention: p66shc (homozygous) deletion / null
median lifespan increased 27.86% (significant)
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Lifespan Observation Mus musculus (AKR/J)
  • Environment Intervention: irradiation
lifespan increased 5.65% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: CEBPA deletion / null
  • Gene Intervention: CEBPB over-expression
mean lifespan increased 21.94% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Bub3 loss of function
  • Gene Intervention: Rae1 loss of function
lifespan increased 12% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: cat over-expression
lifespan increased 20% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Cdkn1a deletion / null
mean lifespan increased 33.33% (significant)
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Lifespan Observation Mus musculus (Zmpste24-/-)
  • Compound Intervention: Recombinant human IGF-1 (1 mg/kg/day)
median lifespan increased 16.67% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Chk2 loss of function
mean lifespan increased 240% (significant)
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Lifespan Observation Mus musculus (129Sv/J)
  • Gene Intervention: clk-1 loss of function
mean lifespan increased 14.44% (significant)
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Lifespan Observation Mus musculus (129Sv/J × Balb/c )
  • Gene Intervention: clk-1 loss of function
mean lifespan increased 30.67% (significant)
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Lifespan Observation Mus musculus (C57BL/6) male
  • Gene Intervention: Prkar2b deletion / null
median lifespan increased 13.69% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Environment Intervention: Dietary restriction
mean lifespan increased 39.83% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Environment Intervention: Dietary restriction
mean lifespan increased 32.49% (significant)
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Lifespan Observation Mus musculus (CByB6F1) male
  • Environment Intervention: Dietary restriction
mean lifespan increased 37.54% (significant)
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Lifespan Observation Mus musculus (CByB6F1) female
  • Environment Intervention: Dietary restriction
mean lifespan increased 28.17% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: N-acetyl-1-cysteine (5 g/L of drinking water)
median lifespan increased 12.2% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: N-acetyl-1-cysteine (10 g/L of drinking water)
median lifespan increased 21.95% (significant)
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Lifespan Observation Mus musculus (ICR/CD-1) female
  • Environment Intervention: Environmental enrichment
median lifespan increased 6.52% (significant)
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Lifespan Observation Mus musculus (heterogeneous genetic background) male
  • Gene Intervention: Prop1 (df) loss of function
median lifespan increased 48.64% (significant)
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Lifespan Observation Mus musculus (heterogeneous genetic background) male
  • Gene Intervention: Prop1 (df) loss of function
  • Compound Intervention: porcine growth hormone (4 micrograms/g body weight per day)
median lifespan increased 6.48%
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Lifespan Observation Mus musculus (Jc1:ICR) male
  • Environment Intervention: High polyamine diet
median lifespan increased 23.81% (significant)
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Lifespan Observation Mus musculus (Jc1:ICR) male
  • Environment Intervention: Low polyamine diet
median lifespan increased 3.81%
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Lifespan Observation Mus musculus (Mixed 129/Sv and C57BL6)
  • Gene Intervention: huntingtin (deltaQ-htt) unknown
median lifespan increased 18.03% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Trp53 loss of function
lifespan increased 23% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) male
  • Gene Intervention: GHA loss of function
median lifespan increased 18.07% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) female
  • Gene Intervention: GHA loss of function
median lifespan increased 32.86% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) male
  • Gene Intervention: Ghrhr loss of function
lifespan increased 23.36% (significant)
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Lifespan Observation Mus musculus (C57BL/6J) female
  • Gene Intervention: Ghrhr loss of function
lifespan increased 24.85% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 5.13% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 9.52% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 13.85% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 21.15% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
median lifespan increased 19.34% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 15% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 16% (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 7% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 5% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 8% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: rapamycin (2.24 mg/kg/day)
mean lifespan increased 15% (significant)
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Lifespan Observation Mus musculus (C3H/Sn) female
  • Compound Intervention: phenformin (5 mg/mouse 5 treatments/week)
mean lifespan increased 21.11% (significant)
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Lifespan Observation Mus musculus (C3H/Sn) female
  • Compound Intervention: phenformin (5 mg/mouse 5 treatments/week)
max lifespan increased 28.37% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 6.67%
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan increased 13.13% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
mean lifespan increased 7.95% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Surf1 loss of function
median lifespan increased 21.25% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Igfr1 loss of function
lifespan increased 33.1% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Igfr1 loss of function
lifespan increased 16.07% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Irs2 loss of function
median lifespan increased 17.24% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: par-4 over-expression
mean lifespan increased 16.67% (significant)
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) male
  • Gene Intervention: NAS1 (-/-) deletion / null
median lifespan increased 30% (significant)
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) male
  • Gene Intervention: NAS1 (+/-) deletion / null
median lifespan increased 5%
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) female
  • Gene Intervention: NAS1 (+/-) deletion / null
median lifespan increased 17.65% (significant)
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Lifespan Observation Mus musculus (129Sv and C57BL/6 mixed) female
  • Gene Intervention: NAS1 (-/-) deletion / null
median lifespan increased 23.53% (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: SOD1 (CuZnSOD-Tg) over-expression
  • Gene Intervention: CAT (CAT-Tg) over-expression
mean lifespan increased 0.03%
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Lifespan Observation Mus musculus (C57BL6)
  • Gene Intervention: Ink4/Arf (Tg (het)) over-expression
mean lifespan increased 2.75%
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Lifespan Observation Mus musculus (C57BL6)
  • Gene Intervention: Ink4/Arf (Tg/Tg) over-expression
mean lifespan increased 17.31% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: pappa deletion / null
mean lifespan increased 37.54% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Prop1 loss of function
mean lifespan increased 67.97% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Prop1 loss of function
mean lifespan increased 48.82% (significant)
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Lifespan Observation Mus musculus (Swiss) female
  • Compound Intervention: 2,4-dinitrophenol (1 mg/L in drinking water)
mean lifespan increased 7.08% (significant)
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Lifespan Observation Mus musculus (wild)
  • Environment Intervention: Caloric restriction
max lifespan increased 14.11% (significant)
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Lifespan Observation Mus musculus (Line A1) male
  • Gene Intervention: Fox01 over-expression
mean lifespan increased 1.92% (significant)
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Lifespan Observation Mus musculus (Line A1) female
  • Gene Intervention: Fox01 over-expression
mean lifespan increased (significant)
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Lifespan Observation Mus musculus (Line A2) male
  • Gene Intervention: Fox01 over-expression
mean lifespan increased (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: nordihydroguaiaretic acid (NDGA) (417 mg/kg/day)
median lifespan increased 12.09% (significant)
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Lifespan Observation Mus musculus (UM-HET3) male
  • Compound Intervention: aspirin (3.3 mg/kg/day)
median lifespan increased 8.02% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 14.09% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
median lifespan increased 17.52% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
max lifespan increased 3.29% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 20.71% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 6.17% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
median lifespan increased 6.6% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan increased 7.06% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
max lifespan increased 2.66%
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Lifespan Observation Mus musculus male
  • Gene Intervention: Nas-1 deletion / null
median lifespan increased 25% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Nas-1 deletion / null
median lifespan increased 25% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Nas-1 loss of function
median lifespan increased 20% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Nas-1 loss of function
median lifespan increased 4%
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Lifespan Observation Mus musculus female
  • Gene Intervention: lrs1 deletion / null
mean lifespan increased 7.03% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: lrs1 deletion / null
median lifespan increased 10.14% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: lrs1 deletion / null
median lifespan increased 15.61% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: lrs1 deletion / null
mean lifespan increased 14.12% (significant)
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Lifespan Observation Mus musculus (C57BL/6)
  • Environment Intervention: Intermittent feeding plus polyphenols
median lifespan increased 45.65% (significant)
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Lifespan Observation Mus musculus (C57BL/6)
  • Environment Intervention: Intermittent feeding
median lifespan increased 36.96% (significant)
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