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Showing results 1 - 61 of 61:
Lifespan Observation Mus musculus (Mixed genetic background)
  • Gene Intervention: Terc deletion / null
lifespan decreased (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: MsrA deletion / null
lifespan decreased (significant)
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Lifespan Observation Mus musculus (R722W/R722W)
  • Gene Intervention: XPD non-null recessive
lifespan decreased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Terf2 over-expression
lifespan decreased (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Zdhhc13 loss of function
median lifespan decreased (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Pparg (P465L) non-null dominant
  • Gene Intervention: Ins2 (Akita) unknown
median lifespan decreased (significant)
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Lifespan Observation Mus musculus (AKR/J)
  • Environment Intervention: irradiation
lifespan decreased -9.57% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Arntl deletion / null
lifespan decreased -64.52% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Arntl deletion / null
lifespan decreased -64.52% (significant)
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Lifespan Observation Mus musculus (WW6/C57BL/6)
  • Gene Intervention: Atm deletion / null
mean lifespan decreased -37.5% (significant)
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Lifespan Observation Mus musculus (Brca1Δ11/Δ11 p53 +/−)
  • Gene Intervention: Brca1 deletion / null
mean lifespan decreased -25% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Bub1b loss of function
mean lifespan decreased -60% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Rae1 loss of function
mean lifespan decreased -8.33%
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Lifespan Observation Mus musculus
  • Gene Intervention: Casp2 loss of function
max lifespan decreased -9.33% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: cav1 loss of function
mean lifespan decreased -50% (significant)
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Lifespan Observation Mus musculus (C57BL/6) female
  • Gene Intervention: Prkar2b deletion / null
median lifespan decreased -2.41%
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Lifespan Observation Mus musculus
  • Gene Intervention: Zmpste24 deletion / null
mean lifespan decreased -55% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: TRp63 loss of function
median lifespan decreased -21.49% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Efemp1 loss of function
median lifespan decreased -19.13% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Efemp1 loss of function
max lifespan decreased -28.82% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: fgf23 loss of function
mean lifespan decreased -66.67% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: fxn loss of function
mean lifespan decreased -75% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: GH1 gain of function
mean lifespan decreased -48.75% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (HER-2/neu) female
  • Compound Intervention: metformin (100 mg/kg 5 doses/week)
max lifespan decreased -11.11% (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: AIMP3 over-expression
median lifespan decreased -50% (significant)
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Lifespan Observation Mus musculus (129SvEv-C57BL/6 mixed genetic background)
  • Gene Intervention: Top3b deletion / null
mean lifespan decreased -37.5% (significant)
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Lifespan Observation Mus musculus (mixed genetic background of C57BL/6 and 129SvEv) female
  • Gene Intervention: Chip loss of function
median lifespan decreased -55.2% (significant)
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Lifespan Observation Mus musculus (mixed genetic background of C57BL/6 and 129SvEv) male
  • Gene Intervention: Chip loss of function
median lifespan decreased -68.8% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Sirt6 loss of function
median lifespan decreased -93.42% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: htr1b loss of function
mean lifespan decreased -18.75% (significant)
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Lifespan Observation Mus musculus (C57BL/6J and C3H/J mixed background)
  • Gene Intervention: Kl loss of function
mean lifespan decreased -83.37% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Lmna loss of function
mean lifespan decreased -91.78% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Mcm2 loss of function
mean lifespan decreased -50% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Msh2 loss of function
mean lifespan decreased -50% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Nos3 loss of function
mean lifespan decreased -12.5% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: Pola loss of function
mean lifespan decreased -52% (significant)
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: SOD1 (CuZnSOD-Tg) over-expression
mean lifespan decreased -0.76%
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: CAT (CAT-Tg) over-expression
mean lifespan decreased -0.65%
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Lifespan Observation Mus musculus (C57BL/6J)
  • Gene Intervention: SOD1 (CuZnSOD-Tg) over-expression
  • Gene Intervention: SOD2 (MnSOD-Tg) over-expression
mean lifespan decreased -2.49%
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Lifespan Observation Mus musculus male
  • Gene Intervention: Ppm1d loss of function
mean lifespan decreased -25% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: Ppm1d loss of function
max lifespan decreased -24.69% (significant)
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Lifespan Observation Mus musculus female
  • Gene Intervention: Ppm1d loss of function
mean lifespan decreased -2.48%
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Lifespan Observation Mus musculus female
  • Gene Intervention: Ppm1d loss of function
max lifespan decreased -8.97%
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Lifespan Observation Mus musculus
  • Gene Intervention: Prdx1 loss of function
lifespan decreased -14.29% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) female
  • Gene Intervention: PARP-1 (1xhPARP-1) over-expression
median lifespan decreased -19.35% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) female
  • Gene Intervention: PARP-1 (2xhPARP-1) over-expression
median lifespan decreased -22.92% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) male
  • Gene Intervention: PARP-1 (2xhPARP-1) over-expression
median lifespan decreased -21.71% (significant)
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Lifespan Observation Mus musculus (Mixed background (B6;129P2OlaHsd)) male
  • Gene Intervention: PARP-1 (1xhPARP-1) over-expression
median lifespan decreased -0.75%
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Lifespan Observation Mus musculus (wild)
  • Environment Intervention: Caloric restriction
mean lifespan decreased -2.01% (significant)
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Lifespan Observation Mus musculus (Line A2) female
  • Gene Intervention: Fox01 over-expression
mean lifespan decreased (significant)
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: nordihydroguaiaretic acid (NDGA) (417 mg/kg/day)
median lifespan decreased -0.76%
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Lifespan Observation Mus musculus (UM-HET3) female
  • Compound Intervention: aspirin (3.3 mg/kg/day)
median lifespan decreased -0.76%
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
max lifespan decreased -9.14% (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan decreased -3.14%
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
median lifespan decreased (significant)
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Lifespan Observation Mus musculus (SHR)
  • Compound Intervention: 1, 1-Dimethylbiguanide hydrochloride (100 mg/kg)
mean lifespan decreased -12.8% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: clock deletion / null
mean lifespan decreased -12.75% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: sod-2 loss of function
median lifespan decreased -43.37% (significant)
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Lifespan Observation Mus musculus
  • Gene Intervention: sod-2 loss of function
max lifespan decreased -13.8% (significant)
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Lifespan Observation Mus musculus male
  • Gene Intervention: eIF-5A2 over-expression
mean lifespan decreased -66.67% (significant)
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