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Showing results 1 - 79 of 79:
Lifespan Observation Drosophila melanogaster
  • Gene Intervention: beach1 deletion / null
lifespan decreased (significant)
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Lifespan Observation Drosophila melanogaster (DJ-1α)
  • Gene Intervention: DJ-1alpha RNAi knockdown
lifespan decreased -55.26% (significant)
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Lifespan Observation Drosophila melanogaster (w1118) female
  • Gene Intervention: NIP RNAi knockdown
median lifespan decreased -75% (significant)
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Lifespan Observation Drosophila melanogaster (UCP5KO) female
  • Gene Intervention: Bmcp loss of function
mean lifespan decreased -7.89% (significant)
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Lifespan Observation Drosophila melanogaster (UCP5KO) male
  • Gene Intervention: Bmcp loss of function
mean lifespan decreased -21.57% (significant)
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Lifespan Observation Drosophila melanogaster (UCP5KO)
  • Gene Intervention: Bmcp loss of function
mean lifespan decreased -8.85% (significant)
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Lifespan Observation Drosophila melanogaster (UCP5KO) male
  • Gene Intervention: Bmcp loss of function
mean lifespan decreased -17.52% (significant)
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Lifespan Observation Drosophila melanogaster (UCP5KO) male
  • Gene Intervention: Bmcp loss of function
mean lifespan decreased -3.47%
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Lifespan Observation Drosophila melanogaster
  • Gene Intervention: Cdk5 loss of function
mean lifespan decreased -36.36% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: CG7207 loss of function
mean lifespan decreased -75% (significant)
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Lifespan Observation Drosophila melanogaster female
  • Gene Intervention: CG7207 loss of function
mean lifespan decreased -71.43% (significant)
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Lifespan Observation Drosophila melanogaster (DJ-1βA286)
  • Gene Intervention: dj-1beta loss of function
mean lifespan decreased -24% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (x39) loss of function
mean lifespan decreased -96.17% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (human SOD1 driven by D42-GAL4) over-expression
  • Gene Intervention: SOD1 (x39) loss of function
mean lifespan decreased -67.43% (significant)
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Lifespan Observation Drosophila melanogaster male
  • Gene Intervention: SOD1 (human SOD1 driven by D42-GAL4) over-expression
  • Gene Intervention: SOD1 (x39) loss of function
mean lifespan decreased -27.2% (significant)
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Lifespan Observation Drosophila melanogaster (FLP3) male
  • Gene Intervention: SOD2 (mSOD2E) over-expression
mean lifespan decreased -2.14%
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Lifespan Observation Drosophila melanogaster (FLP3) male
  • Gene Intervention: CAT (CAT2A2) over-expression
mean lifespan decreased -6.86% (significant)
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Lifespan Observation Drosophila melanogaster (FLP3) male
  • Gene Intervention: CAT (CAT2A2) over-expression
mean lifespan decreased -8.2% (significant)
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Lifespan Observation Drosophila melanogaster (FLP3) male
  • Gene Intervention: SOD2 (mSOD3C) over-expression
  • Gene Intervention: CAT (CAT2A2) over-expression
mean lifespan decreased -6.76% (significant)
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Lifespan Observation Drosophila melanogaster (w1118) female
  • Gene Intervention: atg7 loss of function
  • Compound Intervention: spermidine (1 mM)
median lifespan decreased -12.5% (significant)
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Lifespan Observation Drosophila melanogaster (w1118) female
  • Gene Intervention: atg7 loss of function
  • Compound Intervention: spermidine (0.1 mM)
median lifespan decreased -12.5% (significant)
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Lifespan Observation Drosophila melanogaster (w1118) female
  • Gene Intervention: atg7 loss of function
  • Compound Intervention: spermidine (0.01 mM)
median lifespan decreased -12.5% (significant)
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Lifespan Observation Drosophila melanogaster (EP(3)3583-18) male
  • Gene Intervention: hsp22 deletion / null
mean lifespan decreased -28.62% (significant)
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Lifespan Observation Drosophila melanogaster (EP(3)3247) male
  • Gene Intervention: hsp22 (elav-GAL4) over-expression
median lifespan decreased -7.14% (significant)
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Lifespan Observation Drosophila melanogaster (Outbred population caught in early October 2006 in a vineyard ne) female
  • Environment Intervention: dietary restriction
median lifespan decreased -31.82% (significant)
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Lifespan Observation Drosophila melanogaster female
  • Gene Intervention: mnt deletion / null
mean lifespan decreased -32.26% (significant)
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Lifespan Observation Drosophila melanogaster female
  • Gene Intervention: mnt deletion / null
mean lifespan decreased -16.13% (significant)
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Lifespan Observation Drosophila melanogaster (K33) female
  • Gene Intervention: rut1 loss of function
median lifespan decreased -60% (significant)
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Lifespan Observation Drosophila melanogaster (K33) female
  • Gene Intervention: rut1 loss of function
max lifespan decreased -43.84% (significant)
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Lifespan Observation Drosophila melanogaster (K33) female
  • Gene Intervention: rut2080 loss of function
median lifespan decreased -56% (significant)
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Lifespan Observation Drosophila melanogaster (K33) female
  • Gene Intervention: rut2080 loss of function
max lifespan decreased -52.05% (significant)
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Lifespan Observation Drosophila melanogaster (K33) male
  • Gene Intervention: rut2080 loss of function
median lifespan decreased -36.36% (significant)
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Lifespan Observation Drosophila melanogaster (K33) male
  • Gene Intervention: rut2080 loss of function
max lifespan decreased -46.48% (significant)
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Lifespan Observation Drosophila melanogaster (ELAV-GeneSwitch) female
  • Gene Intervention: Dmp53 (259H) deletion / null
mean lifespan decreased (significant)
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Lifespan Observation Drosophila melanogaster (ELAV-GeneSwitch) female
  • Gene Intervention: Dmp53 (259H) deletion / null
mean lifespan decreased -7.84% (significant)
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Lifespan Observation Drosophila melanogaster (ELAV-GeneSwitch) female
  • Gene Intervention: Dmp53 (259H) deletion / null
median lifespan decreased -17.86% (significant)
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Lifespan Observation Drosophila melanogaster (ELAV-GeneSwitch) female
  • Gene Intervention: Dmp53 (259H) deletion / null
max lifespan decreased -4.65%
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Lifespan Observation Drosophila melanogaster (ELAV-GeneSwitch) female
  • Gene Intervention: Dmp53 (259H) deletion / null
max lifespan decreased -7.32% (significant)
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Lifespan Observation Drosophila melanogaster (ELAV-GeneSwitch) female
  • Gene Intervention: Dmp53 (R155H) dominant negative
max lifespan decreased -3.33%
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: Su(var)2-502/+ loss of function
median lifespan decreased -5.58% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: Su(var)2-502/+ loss of function
max lifespan decreased -0.93% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) female
  • Gene Intervention: Su(var)2-502/+ loss of function
max lifespan decreased -3.64% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) female
  • Gene Intervention: Su(var)2-502/+ loss of function
median lifespan decreased -8.72% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) female
  • Gene Intervention: Dp(2;2)P90/+ loss of function
max lifespan decreased -4.18% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: Dp(2;2)P90/+ loss of function
max lifespan decreased -7.32% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: Dp(2;2)P90/+ loss of function
median lifespan decreased -0.9% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: Su(var)2-1^01/+ loss of function
median lifespan decreased -4.01% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: Su(var)2-1^01/+ loss of function
max lifespan decreased -10.66% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) female
  • Gene Intervention: E2F^91/+ loss of function
max lifespan decreased -1.29% (significant)
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Lifespan Observation Drosophila melanogaster (w m4) male
  • Gene Intervention: E2F^91/+ loss of function
median lifespan decreased -4.83% (significant)
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Lifespan Observation Drosophila melanogaster (dFOXO21a/+) female
  • Gene Intervention: dFOXO deletion / null
  • Environment Intervention: Dietary restriction
median lifespan decreased -25% (significant)
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Lifespan Observation Drosophila melanogaster (dFOXO21a/+) female
  • Gene Intervention: dFOXO deletion / null
  • Environment Intervention: Dietary restriction
median lifespan decreased -47.3% (significant)
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Lifespan Observation Drosophila melanogaster (dFOXO21a/+) female
  • Gene Intervention: dFOXO deletion / null
  • Environment Intervention: Dietary restriction
median lifespan decreased -23.81% (significant)
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Lifespan Observation Drosophila melanogaster (dFOXO21a/+) female
  • Gene Intervention: dFOXO deletion / null
  • Environment Intervention: Dietary restriction
median lifespan decreased -37.84% (significant)
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Lifespan Observation Drosophila melanogaster (dFOXO21a/+) female
  • Gene Intervention: dFOXO deletion / null
  • Environment Intervention: Dietary restriction
median lifespan decreased -32.08% (significant)
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Lifespan Observation Drosophila melanogaster (dFOXO21a/+) female
  • Gene Intervention: dFOXO deletion / null
  • Environment Intervention: Dietary restriction
median lifespan decreased -50% (significant)
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Lifespan Observation Drosophila melanogaster (Dahomey-Alstonville)
  • Gene Intervention: Dahomey normal
mean lifespan decreased -2.2%
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Lifespan Observation Drosophila melanogaster (Dahomey-Alstonville)
  • Gene Intervention: Japan normal
mean lifespan decreased -6.34% (significant)
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Lifespan Observation Drosophila melanogaster (Hawaii-Alstonville)
  • Gene Intervention: Japan normal
mean lifespan decreased -22.34% (significant)
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Lifespan Observation Drosophila melanogaster (Seattle-Alstonville)
  • Gene Intervention: Dahomey normal
mean lifespan decreased -2.68% (significant)
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Lifespan Observation Drosophila melanogaster (Seattle-Alstonville)
  • Gene Intervention: Japan normal
mean lifespan decreased -4.38%
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Lifespan Observation Drosophila melanogaster (SODn108/TM3 (SODn108))
  • Environment Intervention: Dietary enhancement
mean lifespan decreased (significant)
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Lifespan Observation Drosophila melanogaster (OE−/SM5 × Catn1/TM3 (Catn1))
  • Environment Intervention: Dietary enhancement
mean lifespan decreased (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (1 µM/100 ml)
max lifespan decreased -5.26% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (3 µM/100 ml)
max lifespan decreased -12.28% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (5 µM/100 ml)
max lifespan decreased -24.56% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (10 µM/100 ml)
max lifespan decreased -36.84% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (1 µM/100 ml)
mean lifespan decreased -12.82% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (3 µM/100 ml)
mean lifespan decreased -17.95% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (5 µM/100 ml)
mean lifespan decreased -30.77% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) female
  • Compound Intervention: genistein (10 µM/100 ml)
mean lifespan decreased -41.03% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (1 µM/100 ml)
max lifespan decreased -7.27% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (3 µM/100 ml)
max lifespan decreased -12.73% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (5 µM/100 ml)
max lifespan decreased -27.27% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (10 µM/100 ml)
max lifespan decreased -40% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (1 µM/100 ml)
mean lifespan decreased -15.79% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (3 µM/100 ml)
mean lifespan decreased -18.42% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (5 µM/100 ml)
mean lifespan decreased -31.58% (significant)
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Lifespan Observation Drosophila melanogaster (Oregon-R-C (OR)) male
  • Compound Intervention: genistein (10 µM/100 ml)
mean lifespan decreased -42.11% (significant)
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