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Observation 938

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Species Mus musculus
Lifespan 300 days
Reference Lifespan
Lifespan Change
Lifespan Measure median
Lifespan Effect decreased
Significance significant
Citation Saleem AN, Chen YH, Baek HJ, Hsiao YW, Huang HW, Kao HJ, Liu KM, Shen LF, Song IW, Tu CP, Wu JY, Kikuchi T, Justice MJ, Yen JJ, Chen YT. (2010). Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. PLoS Genet. [pubmed]
A mutation in the Zdhhc13 gene, which codes for a palmitoyl transferase enzyme, results in shortened life span, alopecia, osteoporosis, and systemic amyloidosis.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Zdhhc13 loss of function