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Observation 891

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Species
Strain
Lifespan 21 days
Reference Lifespan 24 days
Lifespan Change -12.5%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Corby-Harris V, Drexler A, Watkins de Jong L, Antonova Y, Pakpour N, Ziegler R, Ramberg F, Lewis EE, Brown JM, Luckhart S, Riehle MA. (2010). Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopheles stephensi mosquitoes. PLoS Pathog. [pubmed]
Details
A. stephensi expressing an active variant of the mosquito Akt under the control of the midgut-specific carboxypeptidase (CP) promoter had a reduced life span relative to control animals.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Akt over-expression