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Observation 89

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Species Caenorhabditis elegans
Strain Bristol N2
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Vanfleteren JR, De Vreese A. (1995). The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans.. FASEB J. 9: 1355-61. [pubmed]
Details

Life-span extension by age-1 is up to 100% in axenic culture.

Other phenotypes: A recessive allele of age-1 increases life-span up to 100% [pubmed] [pubmed]. Life-span extension by age-1 is up to 100% in axenic culture [pubmed]. Mutant is dauer constitutive [pubmed]. Mutants display lower low brood size and increased embryonic lethality [pubmed]. age-1 mutants also have elevated levels of superoxide dismutase and catalase activities [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
age-1 non-null recessive 174762 View