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Observation 87

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Species Caenorhabditis elegans
Strain Bristol N2
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Friedman DB, Johnson TE. (1988). A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.. Genetics 118: 75-86. [pubmed]
Details

A recessive allele of age-1 increases life-span up to 100%.

Other phenotypes: A recessive allele of age-1 increases life-span up to 100% [pubmed]. Life-span extension by age-1 is up to 100% in axenic culture [pubmed]. Mutant is dauer constitutive [pubmed]. Mutants display lower low brood size and increased embryonic lethality [pubmed]. age-1 mutants also have elevated levels of superoxide dismutase and catalase activities [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
age-1 non-null recessive 174762 View