Sageweb.org > Tools

Observation 85

Export: CSV XML YAML
Related Observations
User Comments

Please login to leave comments.

Species Saccharomyces cerevisiae
Strain W303
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Roy N, Runge KW. (2000). Two paralogs involved in transcriptional silencing that antagonistically control yeast life span.. Curr. Biol. 10: 111-4. [pubmed]
Details

Deletion increases life span by 37%, requires Sir3p for life span extension.

Other phenotypes: Null mutation causes a 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3p phosphorylation.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
ZDS1 deletion / null 855316 View