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Observation 8

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Species Caenorhabditis elegans
Strain Bristol N2
Temperature 25
Lifespan 27 days
Reference Lifespan 17 days
Lifespan Change 58.82%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. (1999). A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegan. Genes Dev. 13: 1438-52. [pubmed]
Details

Loss of function alleles extend life span by 60%.

Other phenotypes: Mutants are dauer constitutive and a gain of function allele can suppress age-1 dauer constitutive phenotype [pubmed]. Dauer constitutive phenotype of pdk-1(sa680) is suppressed by daf-16 [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
pdk-1 sa680 non-null recessive 180475 View