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Observation 736

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change 20%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Resendiz S, Henriksen S, Zorrill. (2006). Transgenic mice with a reduced core body temperature have an increased life span.. Science 314: 825-8. [pubmed]
Details

Overexpression resulted in a 20% increase in median lifespan in females.

Other phenotypes: Overexpression in hypocretin neurons results in mice with elevated hypothalamic temperature and reduction of core body temperature

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Ucp2 over-expression 22228 View