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Observation 730

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change 35%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, Ishizaki-Koizumi S, Hirakawa T, Inoue T, Yodoi J. (2002). Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.. Antioxid. Redox Signal. 4: 693-6. [pubmed]
Details

Overexpression in transgenic mice resulted in extended maximum (35%) lifespan.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Txn1 over-expression 22166 View