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Observation 720

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation . (2005). Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.. Oncogene 24: 2256-70. [pubmed]
Details

Overexpression results in a modest lifespan extension.

Other phenotypes: Overexpression of telomerase results in a high cancer incidence but also a modest lifespan extension accompanied by a lower incidence of some age-related degenerative diseases, in particular those related to kidney function and germline integrity.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Tert over-expression 21752 View