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Observation 719

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation . (2005). XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.. Nat. Genet. 37: 1063-71. [pubmed]
Details

Overexpression results in signs of premature ageing.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Terf2 over-expression 21750 View