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Observation 7

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Species Saccharomyces cerevisiae
Strain PSY316
Mating Type matalpha
Temperature 30
Lifespan 16.2 divisions
Reference Lifespan 21.8 divisions
Lifespan Change -25.69%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Lin SJ, Defossez PA, Guarente L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.. Science 289: 2126-8. [pubmed]
Details

Deletion shortens lifespan.

Other phenotypes: Null mutant sensitive to oxidative stress [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
PDE2 deletion / null 854542 View