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Observation 682

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change 81%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Kirby K, Hu J, Hilliker AJ, Phillips JP. (2002). RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative. Proc. Natl. Acad. Sci. U.S.A. 99: 16162-7. [pubmed]
Details

RNA-mediated silencing of sod2 results in approximately 81% shorter lifespan.

Other phenotypes: RNA interference results in increased oxidative stress and early-onset mortality in young adults

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Sod2 RNAi knockdown 36878 View