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Observation 680

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change 33%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Orr WC, Sohal RS. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.. Science 263: 1128-30. [pubmed]
Details

Overexpression of catalase and Sod1 result in a one-third lifespan extension.

Other phenotypes: Overexpression also results in a slower rate of mortality acceleration, and a delayed loss in physical performance.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Sod1 over-expression