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Observation 65

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Species Saccharomyces cerevisiae
Strain W3031-A
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Sinclair DA, Guarente L. (1997). Extrachromosomal rDNA circles--a cause of aging in yeast.. Cell 91: 1033-42. [pubmed]
Details

The cdc6-1 conditional allele results in an approximately 20% increase in mean life span.

Other phenotypes: At 27C, this allele is defective for replication initiation from the rDNA ARS, resulting in a reduced rate of extrachromosomal rDNA circle accumulation [pubmed]. cdc6-1 allele results in genomic instability at the permissive temperature [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
CDC6 non-null recessive 853244 View