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Observation 633

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change 33%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wil. (2007). Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism . J. Biol. Chem. 282: 32844-55. [pubmed]
Details

Overexpression in skeletal muscle results in extended lifespan at least 33%.

Other phenotypes: Also in an increased number of mitochondria. Transgenic mice ate 60% more than controls but had half the body weight and 10% of the body fat.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Pck1 over-expression 18534 View