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Observation 63

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 28.7 days
Reference Lifespan 19.9 days
Lifespan Change 44.22%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Lakowski B, Hekimi S. (1998). The genetics of caloric restriction in Caenorhabditis elegans.. Proc. Natl. Acad. Sci. U.S.A. 95: 13091-6. [pubmed]

Mutations in unc-26 extend life span

Other phenotypes: Life span extension is proposed to be similar to caloric restriction [pubmed]. Mutants are uncoordinated, slow and have defects in pharyngeal pumping [pubmed][pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
unc-26 e156 non-null recessive 178284 View