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Observation 62

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 22.8 days
Reference Lifespan 21.7 days
Lifespan Change 5.07%
Lifespan Measure mean
Lifespan Effect increased
Significance not significant
Citation Lakowski B, Hekimi S. (1998). The genetics of caloric restriction in Caenorhabditis elegans.. Proc. Natl. Acad. Sci. U.S.A. 95: 13091-6. [pubmed]

The effect of mutations in 15 unc genes on life span was examined with mutations in 14 of these genes (unc-1, -4, -6, -7, -9, -24, -25, -29, -30, -46, -47, -49, -79, and -80) failing to lengthen life span..

Other phenotypes: Mutants are defective for foraging, locomotion, and defecation (McIntire et al., 1996). Mutants are uncoordinated [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
unc-25 e265 loss of function 176713 View