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Observation 611

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change 68%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC. (2007). Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila mela. Nat. Genet. [pubmed]
Details

Overexpression of NF1 increased mean lifespan by 68% in females.

Other phenotypes: It also improved reproductive fitness.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
NF1 over-expression