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Observation 610

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect none
Significance
Citation Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC. (2007). Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila mela. Nat. Genet. [pubmed]
Details

Overexpression of NF1 increased mean lifespan by 49% in males.

Other phenotypes: It also improved reproductive fitness.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
NF1 over-expression