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Observation 61

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 19.2 days
Reference Lifespan 19 days
Lifespan Change 1.05%
Lifespan Measure mean
Lifespan Effect increased
Significance not significant
Citation Lakowski B, Hekimi S. (1998). The genetics of caloric restriction in Caenorhabditis elegans.. Proc. Natl. Acad. Sci. U.S.A. 95: 13091-6. [pubmed]

The effect of mutations in 15 unc genes on life span was examined with mutations in 14 of these genes (unc-1, -4, -6, -7, -9, -24, -25, -29, -30, -46, -47, -49, -79, and -80) failing to lengthen life span.

Mutations in unc-24 have no significant effect on life span.

Other phenotypes: unc-24 (e138) fails to extend male life span [pubmed]. Mutant is uncoordinated and displays irregular movement [pubmed][pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
unc-24 e138 non-null recessive 177594 View