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Observation 600

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change 70%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T, Chen ML, Joiner MA, He. (2002). High-quality life extension by the enzyme peptide methionine sulfoxide reductase.. Proc. Natl. Acad. Sci. U.S.A. 99: 2748-53. [pubmed]
Details

Overexpression in the nervous system extended lifespan by up to 70%.

Other phenotypes: Overexpression in the nervous system increased resistance to oxidative stress, and delayed the onset of senescence-induced decline in activity levels and reproductive capacity.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
MSRA over-expression