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Observation 6

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Species Mus musculus
Strain 129 SvEv
Lifespan 815 days
Reference Lifespan 761 days
Lifespan Change 7.1%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG. (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals.. Nature 402: 309-13. [pubmed]

Mice mutant for p66shc have increased life span of 30%. Homozygous mutants are longer-lived than heterozygotes.

Other phenotypes: p66shc -/- cells are more resistant to apoptosis induced by hydrogen peroxide and UV light[pubmed]. p66shc -/- mice are more resistant to oxidative stress induced by paraquat [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
p66shc heterzygous deletion / null