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Observation 57

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Species Caenorhabditis elegans
Strain N2
Sex male
Temperature 20
Lifespan 37.3 days
Reference Lifespan 21.1 days
Lifespan Change 76.78%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Gems D, Riddle DL. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans.. Genetics 154: 1597-610. [pubmed]

Mutation of unc-13 increased male life span. The effect in hermaphrodites could not be determined directly because all animals died from internal hatching of larvae. To prevent this the fog-2(q71) mutation was employed, which eliminates spermatogenesis in hermaphrodites but not males. In this case, mutation of unc-13 had no effect on hermaphrodite life span but still increased male life span.

Other phenotypes: Mutants are uncoordinated [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
unc-13 non-null recessive 172497 View