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Observation 545

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Species Mus musculus
Strain C57BL/6
Lifespan 2.6 years
Reference Lifespan 2.29 years
Lifespan Change 13.54%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Chen C, Liu Y, Liu Y, Zheng P. (2009). mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2: ra75. [pubmed]
Age-matched 22- to 24-month-old male B6 mice were treated with vehicle or rapamycin (4 mg/kg body weight ip) every other day for 6 weeks. At 30 weeks after the first treatment with rapamycin, 80% of control animals were dead, while only 20% of the rapamycin treated animals were dead.

Compound Interventions

Name Quantity Ncbi Id
rapamycin 4 mg/kg every other day