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Observation 54

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Lifespan 48.9 days
Reference Lifespan 25.6 days
Lifespan Change 91.02%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Murakami S, Johnson TE. (1998). Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene.. Curr. Biol. 8: 1091-4. [pubmed]

Overexpression in transgenic animals increased lifespan stress resistance without altering development or fertility.

A typical tkr-1 transgenic line had approximately 20 copies of tkr-1 as assessed by Southern blots and, as expected, overexpressed tkr-1 mRNA

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
tkr-1 Ex over-expression 192055 View