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Observation 5358

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Species Caenorhabditis elegans
Strain N2
Temperature 20
Lifespan 19.5 days
Reference Lifespan 19.5 days
Lifespan Change
Lifespan Measure max
Lifespan Effect decreased
Significance not significant
Citation Gharbi H, Fabretti F, Bharill P, Rinschen M, Brinkkötter S, Frommolt P, Burst V, Schermer B, Benzing T, Müller RU. (2013). Loss of the Birt-Hogg-Dubé gene product Folliculin induces longevity in a hypoxia-inducible factor dependent manner. Aging Cell :. [pubmed]
Wildtype and flcn-1 deficient worms grown on RNAi against vhl-1 display a nearly identical lifespan.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
flcn-1 ok975 loss of function
vhl-1 HT115 RNAi knockdown