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Observation 5057

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Species Caenorhabditis elegans
Strain daf-2(e1370)
Temperature 20
Lifespan 32 days
Reference Lifespan 32 days
Lifespan Change
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T. (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol. [pubmed]
Details
Long lifespan of daf-2(e1370) mutant worms is not enhanced in worms lacking both cdc-48 and atx-3.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
atx-3 gk193 loss of function
cdc-48.1 tm544 loss of function