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Observation 5055

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Species Caenorhabditis elegans
Strain N2
Temperature 20
Lifespan 23 days
Reference Lifespan 23 days
Lifespan Change
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T. (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol. [pubmed]
Expression of cdc-48.2 shortens lifespan of cdc-48.1(tm544); atx-3(gk193) worms. Mean lifespan is not significantly different than N2 controls.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
atx-3 gk193 loss of function
cdc-48.1 tm544 loss of function
cdc-48.2 over-expression