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Observation 5038

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Species Caenorhabditis elegans
Strain AGD466
Temperature 20
Lifespan 18 days
Reference Lifespan 18 days
Lifespan Change
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. (2011). Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470: 404-8. [pubmed]
Details
AAK-2 (aa 1–321) overexpression increases wild-type lifespan but has no significant effect on worms expressing CRTC-1 (S76A, S179A).

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
aak-2 aa1-321 over-expression