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Observation 5007

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Species Caenorhabditis elegans
Strain trx-1(ok1449);eat-2(ad1116)
Temperature 20
Lifespan 13 days
Reference Lifespan 13 days
Lifespan Change
Lifespan Measure median
Lifespan Effect decreased
Significance significant
Citation Fierro-González JC, González-Barrios M, Miranda-Vizuete A, Swoboda P. (2011). The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. [pubmed]
The inability of trx-1(ok1449) eat-2(ad1116) double mutants to extend lifespan was rescued by expression of Ptrx-1::trx-1::GFP in ASJ neurons. This rescue was not achieved in the same genetic background when trx-1::GFP was expressed from the ges-1 promoter in the intestine. Median lifespan of transgenic worms, expressed in the intestine, was not significantly different than control.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
trx-1 over-expression