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Observation 4981

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Species Mus musculus
Strain SHR
Temperature 22
Lifespan 636 days
Reference Lifespan 636 days
Lifespan Change
Lifespan Measure median
Lifespan Effect decreased
Significance significant
Citation Anisimov VN, Berstein LM, Popovich IG, Zabezhinski MA, Egormin PA, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Kovalenko IG, Poroshina TE. (2011). If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY) 3: 148-57. [pubmed]
Metformin treatment started at the age of 15 months had no significant effect on median lifespan relative to control.

Compound Interventions

Name Quantity Ncbi Id
1, 1-Dimethylbiguanide hydrochloride 100 mg/kg