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Observation 4736

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Species Caenorhabditis elegans
Strain N2
Temperature 22.5
Lifespan 47.3 days
Reference Lifespan 11.9 days
Lifespan Change 297.48%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Houthoofd K, Fidalgo MA, Hoogewijs D, Braeckman BP, Lenaerts I, Brys K, Matthijssens F, De Vreese A, Van Eygen S, Muñoz MJ, Vanfleteren JR. (2005). Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans. Aging Cell 4: 87-95. [pubmed]
Mean lifespan of age-1(m305) mutant was 297% greater than wild type.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
age-1 m305 loss of function