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Observation 4667

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Species Drosophila melanogaster
Strain ELAV-GeneSwitch
Sex female
Temperature 25
Lifespan 57 days
Reference Lifespan 57 days
Lifespan Change
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Bauer JH, Chang C, Bae G, Morris SN, Helfand SL. (2010). Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster. Mech. Ageing Dev. [pubmed]
Details
In a Dmp53 null background, induction of the DN-Dmp53 construct does not lead to life span extension over uninduced controls

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Dmp53 259H deletion / null