Sageweb.org > Tools

Observation 4652

Export: CSV XML YAML
Related Observations
User Comments

Please login to leave comments.

Species Caenorhabditis elegans
Strain N2
Temperature 25
Lifespan 7.5 days
Reference Lifespan 7.5 days
Lifespan Change
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Shibamura A, Ikeda T, Nishikawa Y. (2009). A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. [pubmed]
Details
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with NGM (without liposomes) containing 120 micrograms ascorbic acid was not significantly different than control.

Compound Interventions

Name Quantity Ncbi Id
ascorbic acid 120 micrograms