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Observation 4651

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Species Caenorhabditis elegans
Strain N2
Temperature 25
Lifespan 8.5 days
Reference Lifespan 7.5 days
Lifespan Change 13.33%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Shibamura A, Ikeda T, Nishikawa Y. (2009). A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. [pubmed]
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with NGM (without liposomes) containing 5 mg N-acetyl-cystein (NAC) was not significantly different than control.

Compound Interventions

Name Quantity Ncbi Id
N-acetyl-cystein 5 mg