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Observation 4650

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Species Caenorhabditis elegans
Strain N2
Temperature 25
Lifespan 12.5 days
Reference Lifespan 7.5 days
Lifespan Change 66.67%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Shibamura A, Ikeda T, Nishikawa Y. (2009). A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. [pubmed]
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 240 ml of liposomes containing 10 mg N-acetyl-cystein (NAC) was 46% greater than control.

Compound Interventions

Name Quantity Ncbi Id
N-acetyl-cystein 10 mg