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Observation 4576

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Species Caenorhabditis elegans
Strain fem-1(hc17)
Reference Lifespan
Lifespan Change 26.1%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Lee GD, Wilson MA, Zhu M, Wolkow CA, de Cabo R, Ingram DK, Zou S. (2006). Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 5: 515-24. [pubmed]
Dietary deprivation (DD) enhanced stress resistance. DD enhanced resistance to oxidative stress from paraquat. Adult day 3 fem-1(hc17) worms were transferred to DD or ad libitum (AL) conditions with 2.5 or 6.25 μM paraquat. DD increased mean and maximum survival on both paraquat concentrations, 2.5 μM paraquat, 29.5% increased mean survival; 6.25 μM paraquat, 26.1% increase.

Environment Interventions

Type Body
dietary deprivation Adult worms transferred to plates without food.
paraquat Adult day 3 worms transferred to paraquat (6.25µM).